Department of Natural Products Chemistry 81#, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, No. 103 Road WenHua, Shenyang 110016, P. R. China.
Chem Biodivers. 2010 May;7(5):1245-53. doi: 10.1002/cbdv.200900160.
Four new sesquiterpenes including the novel sesquiterpene lactone (6R)-dehydroxysipanolinolide (1), two new eudesmane-type sesquiterpenes, curcolide (2) and curcodione (3), and a new xanthane-type sesquiterpene, curcumadionol (4), were isolated from Curcuma wenyujin Y. H. Chen et C. Ling, together with five known ones, 5-9. The structures of the new compounds were elucidated by spectroscopic methods. The inhibitory effects of compounds 1-9 on nitric-oxide production in lipopolysaccaride-activated macrophages were evaluated.
从温郁金中分离得到了四个新的倍半萜类化合物，包括新型倍半萜内酯（6R）-去羟基锡兰洛内酯（1）、两个新的艾里莫芬烷型倍半萜类化合物 curcolide（2）和 curcodione（3），以及一个新的黄烷型倍半萜 curcumadionol（4），以及五个已知化合物 5-9。通过光谱方法阐明了新化合物的结构。评估了化合物 1-9 对脂多糖激活的巨噬细胞中一氧化氮产生的抑制作用。
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