Rippe B, Townsley M I, Taylor A E
J Appl Physiol (1985). 1985 May;58(5):1521-7. doi: 10.1152/jappl.1985.58.5.1521.
The filtration coefficient (Kf,c) of the microvessels in isolated dog lungs were studied for whole and diluted blood, whole and diluted plasma, Tyrode's solution, and Tyrode's plus dextran (4%, 63,000 mol wt) perfusates. When whole blood and plasma were diluted, Kf,c increased abruptly at a plasma protein concentration between 4 and 5 g/l, an effect which was not dependent on the erythrocyte mass. Both Tyrode's and Tyrode's plus dextran produced increases in Kf,c (60 and 30%, respectively). The difference in Kf,c measured between these latter perfusates was completely abolished when Kf,c were corrected for viscosity differences. Thus the pulmonary microvasculature responds similarly to the systemic circulation in that complete removal of plasma proteins from the perfusate increases Kf,c by 50%. This effect is independent of erythrocyte mass or colloid osmotic pressure of the perfusate, since perfusion with dextran solutions alone also increased Kf,c.
研究了分离犬肺微血管对全血和稀释血、全血浆和稀释血浆、台氏液以及台氏液加右旋糖酐（4%，分子量63000）灌注液的滤过系数（Kf,c）。当全血和血浆被稀释时，在血浆蛋白浓度为4至5 g/l之间，Kf,c会突然增加，这种效应不依赖于红细胞数量。台氏液和台氏液加右旋糖酐都会使Kf,c增加（分别增加60%和30%）。当对Kf,c进行粘度差异校正后，后两种灌注液之间测得的Kf,c差异完全消除。因此，肺微血管系统与体循环的反应相似，即灌注液中血浆蛋白完全去除会使Kf,c增加50%。这种效应与红细胞数量或灌注液的胶体渗透压无关，因为仅用右旋糖酐溶液灌注也会增加Kf,c。
