Mese Bulent, Bozoglan Orhan, Elveren Serdal, Eroglu Erdinc, Gul Mustafa, Celik Ahmet, Ciralik Harun, Yildirimdemir Halil Ibrahim, Yasim Alptekin
Department of Cardiovascular Surgery, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaraş, Turkey.
Department of Microbiology, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaraş, Turkey.
Med Sci Monit. 2015 Mar 27;21:909-14. doi: 10.12659/MSM.893098.
The aim of this study was to evaluate the effectiveness of linezolid, teicoplanin, and vancomycin in prevention of prosthetic vascular graft infections in a vascular graft infection model.
Fifty rats were divided into 5 groups. A polytetrafluoroethylene graft was implanted on the back of each rat. Methicillin-resistant Staphylococcus aureus (MRSA) strain was inoculated into all rats except Group 1. Group 2 was not given any treatment, Group 3 received linezolid, Group 4 received vancomycin, and Group 5 received teicoplanin. The grafts were removed for microbiological and histological examinations on the 7th day. In addition, C-reactive protein and prealbumin levels and leukocyte counts in obtained blood specimens were determined.
Group 1 did not have infection. Group 2 had bacteria 5.7 × 10(4) CFU/cm(2). Group 3 and Group 4 had less bacterial growth. Group 5 had no bacterial growth. The number of bacteria was significantly higher in Group 2 than in the other experimental groups and the control group (p<0.001). Although there was no bacterial growth in Group 5, it did not significantly differ from Group 3 and Group 4. Group 2 had a significantly higher CRP level and leukocyte count and a significantly lower prealbumin level than the other groups.
Linezolid, teicoplanin, and vancomycin are effective in prevention of prosthetic vascular graft infections.
本研究旨在评估利奈唑胺、替考拉宁和万古霉素在血管移植感染模型中预防人工血管移植感染的有效性。
将50只大鼠分为5组。在每只大鼠背部植入聚四氟乙烯移植物。除第1组外，将耐甲氧西林金黄色葡萄球菌（MRSA）菌株接种到所有大鼠体内。第2组未接受任何治疗，第3组接受利奈唑胺治疗，第4组接受万古霉素治疗，第5组接受替考拉宁治疗。在第7天取出移植物进行微生物学和组织学检查。此外，测定所获血标本中的C反应蛋白、前白蛋白水平和白细胞计数。
第1组未发生感染。第2组有细菌5.7×10⁴CFU/cm²。第3组和第4组细菌生长较少。第5组无细菌生长。第2组的细菌数量显著高于其他实验组和对照组（p<0.001）。虽然第5组无细菌生长，但与第3组和第4组无显著差异。第2组的CRP水平和白细胞计数显著高于其他组，前白蛋白水平显著低于其他组。
利奈唑胺、替考拉宁和万古霉素在预防人工血管移植感染方面有效。
