Atahan E, Gul M, Ergun Y, Eroglu E
Department of Cardiovascular Surgery, School of Medicine, Kahramanmaras Sutcu Imam University, 46100, Turkey.
Eur J Vasc Endovasc Surg. 2007 Aug;34(2):182-7. doi: 10.1016/j.ejvs.2007.03.002. Epub 2007 May 4.
Prophylactic efficiencies of cefazolin, teicoplanin and vancomycin in a dacron graft infection model caused by methicillin-susceptible (MSSA) or -resistant Staphylococcus aureus (MRSA) were investigated.
Prospective, randomized, controlled animal study.
Infections were established subcutaneously in the back of rats by implantation of Dacron prostheses followed by topical inoculation onto grafts of MSSA or MRSA. Experimental groups were as follows: Uncontaminated group (control), MSSA- or MRSA-contaminated and untreated groups, MSSA- or MRSA-contaminated groups treated with cefazolin, teicoplanin or vancomycin by one of three regimens (one day, two days, or three days regimen). Grafts were removed 7 days after the implantation and evaluated by using sonication and quantitative blood agar culture.
Contaminated groups demonstrated graft infections. Cefazolin, teicoplanin and vancomycin profoundly prevented the graft infections in MSSA- or MRSA-contaminated groups. For each antibiotic regimen, the most effective prevention was achieved by the drugs given as three days regimen. For MSSA and MRSA, the order of the effectiveness was as follows: teicoplanin>vancomycin>cefazolin.
As a prophylactic agent, teicoplanin seems to be more effective than vancomycin and cefazolin against vascular graft infections caused by MSSA and MRSA in rats.
研究头孢唑林、替考拉宁和万古霉素在由甲氧西林敏感金黄色葡萄球菌（MSSA）或耐甲氧西林金黄色葡萄球菌（MRSA）引起的涤纶移植物感染模型中的预防效果。
前瞻性、随机、对照动物研究。
通过植入涤纶假体在大鼠背部皮下建立感染，随后在移植物上局部接种MSSA或MRSA。实验组如下：未污染组（对照组）、MSSA或MRSA污染且未治疗组、MSSA或MRSA污染组，通过三种方案之一（一日方案、两日方案或三日方案）用头孢唑林、替考拉宁或万古霉素治疗。植入后7天取出移植物，通过超声处理和定量血琼脂培养进行评估。
污染组出现移植物感染。头孢唑林、替考拉宁和万古霉素能显著预防MSSA或MRSA污染组的移植物感染。对于每种抗生素方案，以三日方案给药的药物预防效果最佳。对于MSSA和MRSA，有效性顺序如下：替考拉宁>万古霉素>头孢唑林。
作为一种预防药物，替考拉宁在预防大鼠由MSSA和MRSA引起的血管移植物感染方面似乎比万古霉素和头孢唑林更有效。
