Coppola Maurizio, Mondola Raffaella
Department of Addiction, ASL CN2, Alba, Italy.
Department of Mental Health, ASL CN1, Saluzzo, Italy.
Basic Clin Pharmacol Toxicol. 2015 Jul;117(1):26-30. doi: 10.1111/bcpt.12399. Epub 2015 Apr 19.
In recent years, the spread of new psychoactive substances has dramatically increased in term of availability of both number of compounds and chemical families. In November 2012, 4,4'-Dimethylaminorex (4,4'-DMAR), a novel synthetic stimulant, was first detected in the Netherlands. Between June 2013 and June 2014, thirty-one deaths associated with the consumption of this new drug have been registered across Europe. In this MiniReview, we have summarized the chemical, pharmacological and toxicological information about this new legal high.
近年来，新精神活性物质的传播在化合物数量和化学家族的可得性方面都急剧增加。2012年11月，新型合成兴奋剂4,4'-二甲基氨基苯丙胺（4,4'-DMAR）首次在荷兰被检测到。在2013年6月至2014年6月期间，欧洲各地已登记了31例与这种新药消费相关的死亡病例。在本综述中，我们总结了关于这种新型合法兴奋剂的化学、药理学和毒理学信息。
