Overturf C L, Wormington A M, Blythe K N, Gohad N V, Mount A S, Roberts A P
Department of Biological Sciences & Institute of Applied Science, University of North Texas, 1155 Union Circle, Denton, TX, 76203, USA.
Department of Biological Sciences, Clemson University, Clemson, SC, 29634, USA.
Comp Biochem Physiol C Toxicol Pharmacol. 2015 May;171:49-54. doi: 10.1016/j.cbpc.2015.01.006. Epub 2015 Mar 25.
Noradrenaline (NA) is the active component of novel antifouling agents and acts by preventing attachment of fouling organisms. The goal of this study was to examine the toxicity of NA to the non-target zooplankton D. magna and C. dubia. Neonates were exposed to one of five concentrations of NA and effects on survival, reproduction and molting were determined. Calculated LC50 values were determined to be 46 and 38 μM in C. dubia and D. magna, respectively. A 10-day C. dubia study found that reproduction metrics were significantly impacted at non-lethal concentrations. In D. magna, concentrations greater than 40 μM significantly impacted molting. A toxicity test was conducted with D. magna using oxidized NA, which yielded similar results. These data indicate that both NA and oxidized NA are toxic to non-target zooplankton. Results obtained from this study can be used to guide future ecological risk assessments of catecholamine-based antifouling agents.
去甲肾上腺素(NA)是新型防污剂的活性成分,其作用是防止污损生物附着。本研究的目的是检测NA对非靶标浮游动物大型溞和 dubia 角突网纹溞的毒性。将幼体暴露于五种浓度的NA之一,测定其对生存、繁殖和蜕皮的影响。计算得出,在 dubia 角突网纹溞和大型溞中,LC50值分别为46 μM和38 μM。一项为期10天的 dubia 角突网纹溞研究发现,在非致死浓度下,繁殖指标受到显著影响。在大型溞中,浓度大于40 μM会显著影响蜕皮。使用氧化型NA对大型溞进行了毒性试验,结果相似。这些数据表明,NA和氧化型NA对非靶标浮游动物均有毒性。本研究所得结果可用于指导未来基于儿茶酚胺的防污剂的生态风险评估。