Huang Hua-Ping, He Mei, Wang Hai-Yan, Zhou Mengjun
Department of Nursing Administration, Mianyang Central Hospital, No. 12, Changjia Alley, Jingzhong Street, Fucheng District, Mianyang, 621000, China.
Department of Statistic, Mianyang Central Hospital, Mianyang, China.
Breast Cancer. 2016 Jul;23(4):568-76. doi: 10.1007/s12282-015-0604-0. Epub 2015 Mar 28.
Psychological issue is the most common co-morbidity of women with breast cancer (BC) after receiving treatment. Effective coping with this problem is significant importance. The aim of this meta-analysis is to evaluate the benefits of mindfulness-based stress reduction (MBSR) on psychological distress among breast cancer survivors.
PUBMED, EMBASE, and the Cochrane Central Register of Controlled Trials were systematically searched from their inception to June 30, 2014. Two reviewers independently reviewed and extracted the data. The primary outcomes of interest were psychological domains. Review Manager 5.3 was used to pool collected data.
Nine articles involving 964 participants were identified. Compared with those in control group, patients in MBSR group have a significant improvement on psychological domains: depression [mean difference (MD), 5.09; 95 % confidence interval (CI), 3.63-6.55; P < 0.00001], anxiety (MD, 2.79; 95 % CI, 1.62-3.96; P < 0.00001), stress (MD, 4.10; 95 % CI, 2.46-5.74; P < 0.00001). MBSR can also improve the overall quality of life (QOL) (MD, -1.16; 95 % CI, -2.21 to -0.12; P = 0.03).
On the basis of our findings, MBSR shows a positive effect on psychological function and QOL of breast cancer survivors. This approach can be recommended to breast cancer patients as a part of their rehabilitation.
心理问题是乳腺癌（BC）女性患者治疗后最常见的合并症。有效应对这一问题至关重要。本荟萃分析的目的是评估基于正念减压疗法（MBSR）对乳腺癌幸存者心理困扰的益处。
系统检索了PUBMED、EMBASE以及Cochrane对照试验中心注册库，检索时间从建库至2014年6月30日。两名研究者独立进行文献筛选和数据提取。主要关注的结局指标为心理领域相关指标。使用Review Manager 5.3软件对收集到的数据进行汇总分析。
共纳入9篇文章，涉及964名参与者。与对照组相比，MBSR组患者在心理领域有显著改善：抑郁[平均差（MD），5.09；95%置信区间（CI），3.63 - 6.55；P < 0.00001]、焦虑（MD，2.79；95% CI，1.62 - 3.96；P < 0.00001）、压力（MD，4.10；95% CI，2.46 - 5.74；P < 0.00001）。MBSR还可改善总体生活质量（QOL）（MD，-1.16；95% CI，-2.21至-0.12；P = 0.03）。
基于我们的研究结果，MBSR对乳腺癌幸存者的心理功能和生活质量有积极影响。该方法可作为康复治疗的一部分推荐给乳腺癌患者。
