Liu Tao, Zhang Yonghui, Lin Hualiang, Lv Xiaojuan, Xiao Jianpeng, Zeng Weilin, Gu Yuzhou, Rutherford Shannon, Tong Shilu, Ma Wenjun
1] Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, 511430, China [2] Environment and Health, Guangdong Provincial Key Medical Discipline of Twelfth Five-Year Plan, Guangzhou, 511430, China.
Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, 511430, China.
Sci Rep. 2015 Mar 30;5:9525. doi: 10.1038/srep09525.
Although erythromelalgia (EM) has been documented in the literature for almost 150 years, it is still poorly understood. To overcome this limitation, we examined the spatial distribution of epidemic EM, and explored the association between temperature fluctuation and epidemic EM outbreaks in China. We searched all peer-reviewed literature on primary epidemic EM outbreaks in China. A two-stage model was used to characterize the relationship between temperature fluctuation and epidemic EM outbreaks. We observed that epidemic EM outbreaks were reported from 13 provinces during 1960-2014 and they mainly occurred between February and March in southern China. The majority of EM cases were middle school students, with a higher incidence rate in female and resident students. The major clinical characteristics of EM cases included burning, sharp, tingling and/or stinging pain in toes, soles and/or dorsum of feet, fever, erythema and swelling. A large "V"-shaped fluctuation of daily average temperature (TM) observed during the epidemic EM outbreaks was significantly associated with the number of daily EM cases (β = 1.22, 95%CI: 0.66 ~ 1.79), which indicated that this "V"-shaped fluctuation of TM probably triggered the epidemic EM outbreaks.
尽管红斑性肢痛症（EM）在文献中已有近150年的记载，但人们对它仍知之甚少。为克服这一局限性，我们研究了流行性EM的空间分布，并探讨了中国温度波动与流行性EM暴发之间的关联。我们检索了所有关于中国原发性流行性EM暴发的同行评审文献。采用两阶段模型来描述温度波动与流行性EM暴发之间的关系。我们观察到，1960年至2014年期间，中国13个省份报告了流行性EM暴发，且主要发生在中国南方的2月和3月。大多数EM病例为中学生，女性和住校学生的发病率较高。EM病例的主要临床特征包括脚趾、脚底和/或脚背出现灼痛、刺痛、麻刺感和/或刺痛，发热，红斑和肿胀。在流行性EM暴发期间观察到的日平均温度（TM）的大幅“V”形波动与每日EM病例数显著相关（β = 1.22，95%CI：0.66 ~ 1.79），这表明TM的这种“V”形波动可能引发了流行性EM暴发。
