Sun Hao, Fessler Jeffrey A, Noll Douglas C, Nielsen Jon-Fredrik
Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan, USA.
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Magn Reson Med. 2016 Feb;75(2):839-44. doi: 10.1002/mrm.25682. Epub 2015 Mar 29.
Small-tip fast recovery (STFR) imaging has been proposed recently as a potential alternative to balanced steady-state free precession (bSSFP). STFR relies on a tailored "tip-up" radio-frequency pulse to achieve comparable signal level as bSSFP, but with reduced banding artifacts and transient oscillations, and is compatible with magnetization-preparation pulses. Previous STFR implementations used two-dimensional or three-dimensional pulses spatially tailored to the accumulated phase calculated from a B0 field map, making the steady-state STFR signal contain some T2* weighting. Here, we propose to replace the spatially tailored pulse with a recently introduced spectrally selective "pre-winding" pulse that is precomputed to a target frequency range. The proposed "spectral-STFR" sequence produces T2/T1-weighted images similar to bSSFP, but with reduced banding and potentially other benefits.
We investigated the steady-state signal properties of spectral-STFR using simulations, and phantom and human volunteer experiments.
Our simulation and experimental results showed that the spectral-STFR sequence has similar signal level and tissue contrast as bSSFP, but has a wider passband and more consistent banding profiles across different tissues (e.g., less hyperintense signal at band edges for low flip angles). Care is needed in designing the spectral radio-frequency pulse to ensure that the small tip angle approximation holds during radio-frequency transmission.
Spectral-STFR has similar tissue contrast as bSSFP but a wider passband and more consistent cerebrospinal fluid/brain tissue contrast across the passband. The spectral-STFR sequence is a potential alternative to bSSFP in some applications. Compared to a spatially tailored STFR sequence, spectral-STFR can be precomputed, is easier to implement in practice, and potentially has more uniform image contrast and minimal T2* weighting.
小角度快速恢复(STFR)成像最近被提议作为平衡稳态自由进动(bSSFP)的一种潜在替代方法。STFR依靠定制的“翻转向上”射频脉冲来实现与bSSFP相当的信号水平,但具有减少的带状伪影和瞬态振荡,并且与磁化准备脉冲兼容。先前的STFR实现使用根据B0场图计算出的累积相位在空间上定制的二维或三维脉冲,使得稳态STFR信号包含一些T2*加权。在此,我们提议用最近引入的针对目标频率范围预先计算的频谱选择性“预缠绕”脉冲来替代空间定制脉冲。所提出的“频谱STFR”序列产生与bSSFP相似的T2/T1加权图像,但具有减少的带状伪影以及潜在的其他优点。
我们使用模拟、体模和人体志愿者实验研究了频谱STFR的稳态信号特性。
我们的模拟和实验结果表明,频谱STFR序列与bSSFP具有相似的信号水平和组织对比度,但具有更宽的通带,并且在不同组织中带状分布更一致(例如,对于低翻转角,带边缘处的高信号强度更低)。在设计频谱射频脉冲时需要注意,以确保在射频传输期间小翻转角近似成立。
频谱STFR与bSSFP具有相似的组织对比度,但通带更宽,并且在整个通带内脑脊液/脑组织对比度更一致。在某些应用中,频谱STFR序列是bSSFP的一种潜在替代方法。与空间定制的STFR序列相比,频谱STFR可以预先计算,在实践中更易于实现,并且可能具有更均匀的图像对比度和最小的T2*加权。