Mossdorf Anne, Ulmer Florian, Junge Karsten, Heidenhain Christoph, Hein Marc, Temizel Ilknur, Neumann Ulf Peter, Schöning Wenzel, Schmeding Maximilian
Department of General, Visceral and Transplantation Surgery, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Department of Anaesthesiology, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Gastroenterol Res Pract. 2015;2015:967951. doi: 10.1155/2015/967951. Epub 2015 Mar 2.
Introduction. The venovenous/portal venous (VVP) bypass technique has generally become obsolete in liver transplantation (LT) today. We evaluated our experience with 163 consecutive LTs that used a VVP bypass. Patients and Methods. The liver transplant program was started in our center in 2010. LTs were performed using an extracorporal bypass device. Results. Mean operative time was 269 minutes and warm ischemic time 43 minutes. The median number of transfusion of packed cells and plasma was 7 and 14. There was no intraoperative death, and the 30-day mortality was 3%. Severe bypass-induced complications did not occur. Discussion. The introduction of a new LT program requires maximum safety measures for all of the parties involved. Both surgical and anaesthesiological management (reperfusion) can be controlled very reliably using a VVP bypass device. Particularly when using marginal grafts, this approach helps to minimise both surgical and anaesthesiological complications in terms of less volume overload, less use of vasopressive drugs, less myocardial injury, and better peripheral blood circulation. Conclusion. Based on our experiences while establishing a new liver transplantation program, we advocate the reappraisal of the extracorporeal VVP bypass.
引言。静脉-静脉/门静脉(VVP)转流技术如今在肝移植(LT)中总体上已过时。我们评估了连续163例采用VVP转流的肝移植手术的经验。
患者与方法。我们中心于2010年启动肝移植项目。肝移植手术使用体外转流装置进行。
结果。平均手术时间为269分钟,热缺血时间为43分钟。浓缩红细胞和血浆的输注中位数分别为7单位和14单位。无术中死亡,30天死亡率为3%。未发生严重的转流相关并发症。
讨论。开展新的肝移植项目需要为所有相关方采取最大程度的安全措施。使用VVP转流装置可以非常可靠地控制手术和麻醉管理(再灌注)。特别是在使用边缘供肝时,这种方法有助于在减少容量超负荷、减少血管活性药物使用、减少心肌损伤以及改善外周血液循环方面将手术和麻醉并发症降至最低。
结论。基于我们在建立新的肝移植项目过程中的经验,我们主张重新评估体外VVP转流。