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腔静脉植入的传统技术与背驮式技术;无需体外静脉-静脉转流。一项对比研究。

Conventional versus piggyback technique of caval implantation; without extra-corporeal veno-venous bypass. A comparative study.

作者信息

Khan Saboor, Silva Michael A, Tan Yu Meng, John Abraham, Gunson Bridget, Buckels John A C, David Mayer A, Bramhall Simon R, Mirza Darius F

机构信息

Liver Unit (Liver Transplantation and Hepatobiliary Surgery), University Hospital Birmingham NHS Trust, Queen Elizabeth, Edgbaston, Birmingham, UK.

出版信息

Transpl Int. 2006 Oct;19(10):795-801. doi: 10.1111/j.1432-2277.2006.00331.x.

Abstract

Conventional orthotopic liver transplantation (CON-LT) involves resection of recipient cava, usually with extra-corporeal circulation (veno-venous bypass, VVB), while in the piggyback technique (PC-LT) the cava is preserved. Along with a temporary portacaval shunt (TPCS), better haemodynamic maintenance is purported with PC-LT. A prospective, consecutive series of 384 primary transplants (2000-2003) were analysed, 138 CON-LT (with VVB) and 246 PC-LT (54 without TPCS). Patient/donor characteristics were similar in the two groups. PC-LT required less usage of fresh-frozen plasma and platelets, intensive care stay, number of patients requiring ventilation after day 1 and total days spent on ventilator. The results were not different when comparing, total operating and warm ischaemia time (WIT), red cell usage, requirement for renal support, day 3 serum creatinine and total hospital stay. TPCS had no impact on outcome other than WIT (P = 0.02). Three patients in PC-LT group (three of 246;1.2%) developed caval outflow obstruction (P = 0.02). There was no difference in short- or long-term graft or patient survival. PC-LT has an advantage over CON-LT unsing VVB with respect to intraoperative blood product usage, postoperative ventilation requirement and ITU stay. VVB is no longer required and TPCS may be used selectively in adult transplantation.

摘要

传统原位肝移植(CON-LT)通常需要在体外循环(静脉-静脉转流,VVB)下切除受者的腔静脉,而背驮式技术(PC-LT)则保留腔静脉。据称,结合临时门腔分流术(TPCS),PC-LT能更好地维持血流动力学。对2000年至2003年连续进行的384例初次移植手术进行了前瞻性分析,其中138例为CON-LT(采用VVB),246例为PC-LT(54例未采用TPCS)。两组患者/供者的特征相似。PC-LT所需的新鲜冰冻血浆和血小板用量更少,重症监护时间更短,术后第1天之后需要通气的患者数量更少,呼吸机使用总天数也更少。在比较总手术时间和热缺血时间(WIT)、红细胞用量、肾脏支持需求、术后第3天血清肌酐水平和总住院时间时,结果并无差异。除WIT外,TPCS对预后无影响(P = 0.02)。PC-LT组有3例患者(246例中的3例;1.2%)发生腔静脉流出道梗阻(P = 0.02)。短期或长期的移植物或患者生存率并无差异。在术中血液制品使用、术后通气需求和重症监护病房停留时间方面,PC-LT比采用VVB的CON-LT更具优势。不再需要VVB,TPCS可在成人移植中选择性使用。

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