Khan Saboor, Silva Michael A, Tan Yu Meng, John Abraham, Gunson Bridget, Buckels John A C, David Mayer A, Bramhall Simon R, Mirza Darius F
Liver Unit (Liver Transplantation and Hepatobiliary Surgery), University Hospital Birmingham NHS Trust, Queen Elizabeth, Edgbaston, Birmingham, UK.
Transpl Int. 2006 Oct;19(10):795-801. doi: 10.1111/j.1432-2277.2006.00331.x.
Conventional orthotopic liver transplantation (CON-LT) involves resection of recipient cava, usually with extra-corporeal circulation (veno-venous bypass, VVB), while in the piggyback technique (PC-LT) the cava is preserved. Along with a temporary portacaval shunt (TPCS), better haemodynamic maintenance is purported with PC-LT. A prospective, consecutive series of 384 primary transplants (2000-2003) were analysed, 138 CON-LT (with VVB) and 246 PC-LT (54 without TPCS). Patient/donor characteristics were similar in the two groups. PC-LT required less usage of fresh-frozen plasma and platelets, intensive care stay, number of patients requiring ventilation after day 1 and total days spent on ventilator. The results were not different when comparing, total operating and warm ischaemia time (WIT), red cell usage, requirement for renal support, day 3 serum creatinine and total hospital stay. TPCS had no impact on outcome other than WIT (P = 0.02). Three patients in PC-LT group (three of 246;1.2%) developed caval outflow obstruction (P = 0.02). There was no difference in short- or long-term graft or patient survival. PC-LT has an advantage over CON-LT unsing VVB with respect to intraoperative blood product usage, postoperative ventilation requirement and ITU stay. VVB is no longer required and TPCS may be used selectively in adult transplantation.
传统原位肝移植(CON-LT)通常需要在体外循环(静脉-静脉转流,VVB)下切除受者的腔静脉,而背驮式技术(PC-LT)则保留腔静脉。据称,结合临时门腔分流术(TPCS),PC-LT能更好地维持血流动力学。对2000年至2003年连续进行的384例初次移植手术进行了前瞻性分析,其中138例为CON-LT(采用VVB),246例为PC-LT(54例未采用TPCS)。两组患者/供者的特征相似。PC-LT所需的新鲜冰冻血浆和血小板用量更少,重症监护时间更短,术后第1天之后需要通气的患者数量更少,呼吸机使用总天数也更少。在比较总手术时间和热缺血时间(WIT)、红细胞用量、肾脏支持需求、术后第3天血清肌酐水平和总住院时间时,结果并无差异。除WIT外,TPCS对预后无影响(P = 0.02)。PC-LT组有3例患者(246例中的3例;1.2%)发生腔静脉流出道梗阻(P = 0.02)。短期或长期的移植物或患者生存率并无差异。在术中血液制品使用、术后通气需求和重症监护病房停留时间方面,PC-LT比采用VVB的CON-LT更具优势。不再需要VVB,TPCS可在成人移植中选择性使用。