Reszec Joanna, Hermanowicz Adam, Rutkowski Robert, Turek Grzegorz, Mariak Zenon, Chyczewski Lech
Department of Medical Pathomorphology, Medical University of Bialystok, Ulica Waszyngtona 13, 15-269 Bialystok, Poland.
Department of Neurosurgery, Medical University of Bialystok, Ulica Marii Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland.
Biomed Res Int. 2015;2015:646853. doi: 10.1155/2015/646853. Epub 2015 Mar 3.
Meningiomas constitute up to 13% of all intracranial tumors. The predictive factors for meningioma have not been unambiguously defined; however some limited data suggest that the expression of matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) may be associated with the presence of peritumoral brain edema (PTBE) and worse clinical outcome. The aim of this study was to analyze the expressions of MMP-9 and VEGF in a group of meningiomas of various grades and to study associations between these two markers and PTBE. The study included patients with supratentorial meningiomas. The patients were divided into low- (G1) and high-grade meningiomas (G2 and G3). PTBE was assessed on MRI. The expressions of VEGF and MMP-9 were determined immunohistochemically. The expression of MMP-9 was observed significantly more often in G3 meningiomas than in lower grade tumors. The presence of stage II or III PTBE was associated with a significant increase in MMP-9 expression. The expression of VEGF did not differ across the PTBE stages. Our findings point to a significant role of MMP-9 and VEGF in the pathogenesis of peritumoral brain edema in low- and high-grade meningiomas.
脑膜瘤占所有颅内肿瘤的比例高达13%。脑膜瘤的预测因素尚未明确界定；然而，一些有限的数据表明，基质金属蛋白酶（MMPs）和血管内皮生长因子（VEGF）的表达可能与瘤周脑水肿（PTBE）的存在及较差的临床结果相关。本研究的目的是分析一组不同分级脑膜瘤中MMP-9和VEGF的表达情况，并研究这两种标志物与PTBE之间的关联。该研究纳入了幕上脑膜瘤患者。患者被分为低级别（G1）和高级别脑膜瘤（G2和G3）。通过磁共振成像（MRI）评估PTBE。采用免疫组织化学方法测定VEGF和MMP-9的表达。观察到G3级脑膜瘤中MMP-9的表达明显高于低级别肿瘤。II期或III期PTBE的存在与MMP-9表达的显著增加相关。VEGF的表达在PTBE各阶段无差异。我们的研究结果表明，MMP-9和VEGF在低级别和高级别脑膜瘤瘤周脑水肿的发病机制中起重要作用。
