Fondell Elinor, O'Reilly É Ilis J, Fitzgerald Kathryn C, Falcone Guido J, Kolonel Laurence N, Park Yikyung, Gapstur Susan M, Ascherio Alberto
a Department of Nutrition , Harvard School of Public Health , Boston , Massachusetts , USA.
b Department of Epidemiology , Harvard School of Public Health , Boston , Massachusetts , USA.
Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(5-6):366-71. doi: 10.3109/21678421.2015.1020813. Epub 2015 Mar 30.
Caffeine is thought to be neuroprotective by antagonizing the adenosine A2A receptors in the brain and thereby protecting motor neurons from excitotoxicity. We examined the association between consumption of caffeine, coffee and tea and risk of amyotrophic lateral sclerosis (ALS). Longitudinal analyses based on over 1,010,000 males and females in five large cohort studies (the Nurses' Health Study, the Health Professionals Follow-up Study, the Cancer Prevention Study II Nutrition Cohort, the Multiethnic Cohort Study, and the National Institutes of Health-AARP Diet and Health Study). Cohort-specific multivariable-adjusted risk ratios (RR) and 95% confidence intervals (CI) estimates of ALS incidence or death were estimated by Cox proportional hazards regression and pooled using random-effects models. Results showed that a total of 1279 cases of ALS were documented during a mean of 18 years of follow-up. Caffeine intake was not associated with ALS risk; the pooled multivariable-adjusted RR comparing the highest to the lowest quintile of intake was 0.96 (95% CI 0.81-1.16). Similarly, neither coffee nor tea was associated with ALS risk. In conclusion, the results of this large study do not support associations of caffeine or caffeinated beverages with ALS risk.
咖啡因被认为可通过拮抗大脑中的腺苷A2A受体而具有神经保护作用，从而保护运动神经元免受兴奋性毒性作用。我们研究了咖啡因、咖啡和茶的摄入量与肌萎缩侧索硬化症（ALS）风险之间的关联。基于五项大型队列研究（护士健康研究、卫生专业人员随访研究、癌症预防研究II营养队列、多民族队列研究以及美国国立卫生研究院-美国退休人员协会饮食与健康研究）中超过101万名男性和女性进行纵向分析。通过Cox比例风险回归估计特定队列多变量调整后的ALS发病率或死亡率的风险比（RR）和95%置信区间（CI），并使用随机效应模型进行汇总。结果显示，在平均18年的随访期间共记录了1279例ALS病例。咖啡因摄入量与ALS风险无关；将摄入量最高五分位数与最低五分位数进行比较的汇总多变量调整RR为0.96（95%CI 0.81 - 1.16）。同样，咖啡和茶均与ALS风险无关。总之，这项大型研究的结果不支持咖啡因或含咖啡因饮料与ALS风险之间存在关联。
