吉西他滨和多西他赛化疗后的后段毒性
Posterior segment toxicity after gemcitabine and docetaxel chemotherapy.
作者信息
Kord Valeshabad Ali, Mieler William F, Setlur Vikram, Thomas Merina, Shahidi Mahnaz
机构信息
*MD, MPH †MD ‡PhD Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois (all authors).
出版信息
Optom Vis Sci. 2015 May;92(5):e110-3. doi: 10.1097/OPX.0000000000000571.
PURPOSE
To report outer retinal disruption and uveal effusion after gemcitabine and docetaxel combination therapy.
CASE REPORT
A 78-year-old woman presented with blurry vision after two cycles of gemcitabine and docetaxel combination chemotherapy for stage IV sarcoma. At presentation, visual acuity was finger counting and 20/25 in the right and left eyes, respectively. Slit-lamp examination and B-scan ultrasonography revealed severe uveal effusion in the right eye and choroidal folds in the left eye. Spectral domain optical coherence tomography showed disruption of photoreceptor inner segment ellipsoid band in the right eye. The patient was monitored weekly with ophthalmic examination and B-scan ultrasonography, while continuing with gemcitabine monotherapy. At 8 weeks follow-up, uveal effusion improved considerably and visual acuity was 20/40 and 20/20 in the right and left eyes, respectively.
CONCLUSIONS
Uveal effusion and outer retinal disruption were reported after gemcitabine and docetaxel chemotherapy. Early detection and close ophthalmic monitoring may allow concurrent cancer treatment and prevention of possible chemotherapy-induced ocular side effects.
目的
报告吉西他滨和多西他赛联合治疗后出现的外层视网膜破坏和葡萄膜渗漏。
病例报告
一名78岁女性在接受两周期吉西他滨和多西他赛联合化疗治疗IV期肉瘤后出现视力模糊。就诊时，右眼视力为指数，左眼视力分别为20/25。裂隙灯检查和B超检查显示右眼有严重的葡萄膜渗漏，左眼有脉络膜皱褶。频域光学相干断层扫描显示右眼光感受器内节椭圆体带破坏。患者每周接受眼科检查和B超检查监测，同时继续接受吉西他滨单药治疗。随访8周时，葡萄膜渗漏明显改善，右眼视力为20/40，左眼视力为20/20。
结论
吉西他滨和多西他赛化疗后报告出现葡萄膜渗漏和外层视网膜破坏。早期发现和密切的眼科监测可能有助于同时进行癌症治疗并预防可能的化疗引起的眼部副作用。
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