Edelmann F
Medizinische Klinik mit Schwerpunkt Kardiologie, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK), Berlin, Deutschland,
Herz. 2015 Apr;40(2):176-84. doi: 10.1007/s00059-015-4215-5.
Heart failure (HF) is a major and growing health problem in western communities. Recent data indicate that more than 50% of patients with the clinical syndrome of HF have a preserved left ventricular ejection fraction (HF with preserved ejection fraction, HFpEF). In contrast to the calculated expectations, the observed incidence of HF is rising. Despite the fact that the relative proportion of patients with preserved left ventricular function is also increasing, other factors, such as ageing of the population and the concomitant change of compound risk factors may also contribute to the actual rise in the incidence of HF. Patients with HF suffer from reduced exercise capacity, impaired quality of life and also from recurrent hospitalization due to HF. Over the past decades, an increase of recurrent HF events has been documented. In contrast to earlier reports in which HFpEF was considered to be more benign than HF with reduced ejection fraction (HFrEF), recent data suggest that once hospitalized for HF, patients with HFpEF and those with HFrEF have a comparable prognosis in terms of morbidity and mortality. Despite increasing clinical and economic relevance, no treatment has yet been shown to convincingly reduce mortality in HFpEF. In contrast, strategies for improving survival have now been established for HFrEF. The problem of HF will continue to be major challenge for the healthcare systems in western communities; therefore, consolidated clinical research is necessary to further improve therapeutic strategies for HFrEF and to generally establish treatment options for HFpEF.
心力衰竭(HF)是西方社会一个日益严重的主要健康问题。最近的数据表明,超过50%的HF临床综合征患者左心室射血分数保留(射血分数保留的心力衰竭,HFpEF)。与预期计算结果相反,观察到的HF发病率正在上升。尽管左心室功能保留的患者相对比例也在增加,但其他因素,如人口老龄化和复合风险因素的伴随变化,也可能导致HF发病率的实际上升。HF患者运动能力下降、生活质量受损,还会因HF反复住院。在过去几十年中,HF复发事件有所增加。与早期报告中认为HFpEF比射血分数降低的心力衰竭(HFrEF)更良性不同,最近的数据表明,一旦因HF住院,HFpEF患者和HFrEF患者在发病率和死亡率方面的预后相当。尽管临床和经济相关性不断增加,但尚未有治疗方法能令人信服地降低HFpEF的死亡率。相比之下,目前已确立了改善HFrEF生存率的策略。HF问题仍将是西方社会医疗系统面临的重大挑战;因此,有必要进行综合临床研究,以进一步改善HFrEF的治疗策略,并普遍确立HFpEF的治疗选择。