Tremoulet Adriana H
Department of Pediatrics, Kawasaki Disease Research Center, Rady Children's Hospital San Diego, University of California , San Diego, CA , USA.
Autoimmunity. 2015 May;48(3):177-80. doi: 10.3109/08916934.2015.1027818. Epub 2015 Mar 30.
While the statins are best known for their cholesterol lowering capabilities, they also appear to have anti-inflammatory, anti-oxidant and endothelial-repairing properties that have raised the question as to whether this class of drugs can be of benefit in non-atherosclerotic, acute and chronic vasculitides. These effects, independent of the lipid-lowering effects, make the statins a class of drugs that are primed for repurposing and being used in disease states where innate and adaptive immunity and endothelial damage play a key role. Thus far, statins have been used in Behcet's, rheumatoid arthritis and Kawasaki disease with some promising results. Further study is needed to better understand the innate and adaptive immunological response to statins in cardiovascular diseases as well as the full potential of statins in acute and chronic inflammatory vasculitides.
虽然他汀类药物以其降低胆固醇的能力而最为人所知，但它们似乎还具有抗炎、抗氧化和内皮修复特性，这引发了一个问题，即这类药物是否对非动脉粥样硬化性急慢性血管炎有益。这些作用独立于降脂作用，使他汀类药物成为一类有望被重新利用并用于先天和适应性免疫以及内皮损伤起关键作用的疾病状态的药物。到目前为止，他汀类药物已用于白塞病、类风湿性关节炎和川崎病，并取得了一些有希望的结果。需要进一步研究，以更好地了解心血管疾病中对他汀类药物的先天和适应性免疫反应，以及他汀类药物在急慢性炎症性血管炎中的全部潜力。
