Deutsch S I, Halperin R, Stanley M, Davis K L
Neurochem Res. 1985 Apr;10(4):491-8. doi: 10.1007/BF00964653.
The effects of chronic administration of quinacrine, a phospholipase A2 inhibitor, on striatal homovanillic acid (HVA) levels and behavioral sensitivity to challenge with a dopamine agonist were examined in rats. Moreover, the ability of chronic phospholipase A2 inhibition to modulate the behavioral supersensitivity and striatal HVA reduction induced by chronic haloperidol administration was also examined. Daily intraperitoneal injection of quinacrine resulted in a significant reduction of striatal HVA levels. Coadministration of haloperidol with quinacrine in this paradigm caused a more profound reduction of striatal HVA levels than either drug administered alone. That this effect of combined administration is not simply due to postsynaptic effects of quinacrine on dopamine receptor sensitivity is suggested by the fact that behavioral supersensitivity was not induced by quinacrine alone nor was the behavioral supersensitivity induced by the quinacrine-haloperidol combination greater than that induced by chronic haloperidol administration alone. There were no effects of any treatment condition on striatal levels of serotonin (5-HT) or 5-hydroxyindoleacetic acid (5-HIAA). These data implicate phospholipase A2 activity in the regulation of dopaminergic transmission.
在大鼠中研究了磷脂酶A2抑制剂奎纳克林长期给药对纹状体高香草酸（HVA）水平以及对多巴胺激动剂激发的行为敏感性的影响。此外，还研究了长期抑制磷脂酶A2调节由长期给予氟哌啶醇引起的行为超敏反应和纹状体HVA降低的能力。每日腹腔注射奎纳克林导致纹状体HVA水平显著降低。在此实验范式中，氟哌啶醇与奎纳克林联合给药比单独给予任何一种药物都能更显著地降低纹状体HVA水平。联合给药的这种效应并非仅仅归因于奎纳克林对多巴胺受体敏感性的突触后效应，因为单独使用奎纳克林不会诱导行为超敏反应，且奎纳克林 - 氟哌啶醇联合用药诱导的行为超敏反应也不大于单独长期给予氟哌啶醇所诱导的行为超敏反应。任何处理条件对纹状体中血清素（5 - HT）或5 - 羟吲哚乙酸（5 - HIAA）水平均无影响。这些数据表明磷脂酶A2活性参与多巴胺能传递的调节。
