抗精神分裂症药物：长期治疗可提高大脑中的多巴胺受体结合力。
Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain.
作者信息
Burt D R, Creese I, Snyder S H
出版信息
Science. 1977 Apr 15;196(4287):326-8. doi: 10.1126/science.847477.
PMID:847477
Abstract
Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25% increase in striatal dopamine receptor binding assayed with [3H]haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.
摘要
用抗精神病药物氟哌啶醇、氟奋乃静和利血平对大鼠进行长期治疗后，用[³H]氟哌啶醇测定纹状体多巴胺受体结合，发现结合增加了20%至25%。受体位点的这种增加可能解释了此类动物对多巴胺受体兴奋剂的行为超敏反应以及接受这些药物治疗的患者的迟发性运动障碍。
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