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反复给予抗精神病药物后，多巴胺代谢增加耐受性的区域差异发展。

Differential regional development of tolerance to increase in dopamine turnover upon repeated neuroleptic administration.

作者信息

Scatton B

出版信息

Eur J Pharmacol. 1977 Dec 15;46(4):363-9. doi: 10.1016/0014-2999(77)90230-8.

DOI:10.1016/0014-2999(77)90230-8
PMID:590344
Abstract

Repeated treatment with haloperidol and sulpiride induced tolerance to the increases in homovanillic and dihydroxyphenyl acetic acids in the striatum, nucleus accumbens, tuberculum olfactorium and frontal cortex of the rat. The threshold dose inducing this effect appeared to be lower in the striatum than in the limbic regions. Similar results were found in the frontal cortex by measuring dopamine utilization. Moreover, tolerance developed earlier in the striatum than in the limbic areas. The possible reasons are discussed for the differential development of tolerance in the various DA areas investigated.

摘要

用氟哌啶醇和舒必利反复治疗可使大鼠纹状体、伏隔核、嗅结节和额叶皮质中高香草酸和二羟基苯乙酸的升高产生耐受性。诱导这种效应的阈剂量在纹状体中似乎低于边缘区域。通过测量多巴胺利用率在额叶皮质也发现了类似结果。此外，纹状体比边缘区域更早产生耐受性。文中讨论了在所研究的各个多巴胺区域耐受性差异发展的可能原因。

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Differential regional development of tolerance to increase in dopamine turnover upon repeated neuroleptic administration.反复给予抗精神病药物后，多巴胺代谢增加耐受性的区域差异发展。
Eur J Pharmacol. 1977 Dec 15;46(4):363-9. doi: 10.1016/0014-2999(77)90230-8.
2
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Effects of chronic treatment with 1-sulpiride and haloperidol on central dopamine turnover evaluated in dopamine cell body and nerve terminal-rich areas.在富含多巴胺细胞体和神经末梢的区域评估1-舒必利和氟哌啶醇长期治疗对中枢多巴胺代谢的影响。
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