Schoenen J, Lotstra F, Vierendeels G, Reznik M, Vanderhaeghen J J
Neurology. 1985 Jun;35(6):881-90. doi: 10.1212/wnl.35.6.881.
Several neuropeptides were immunohistologically studied in normal human spinal cords. Substance P, methionine-enkephalin, leucine-enkephalin, and cholecystokinin positive fibers were found in all cytoarchitectonic layers, with a specific distribution pattern for each peptide. Somatostatin, oxytocin, and vasopressin immunoreactivities were restricted to particular spinal layers. Perikarya and proximal dendrites were visualized and classified by comparison with previous Golgi analyses. Substance P was contained in "radiate cells" of layer III, methionine-enkephalin in marginal neurons as well as in layer II "stellate cells," and somatostatin in layer II "islet cells." Several results differed from those reported in other species. Chemical neuroanatomy may provide new insights into the neuronal organization of the human spinal cord.
对正常人脊髓中的几种神经肽进行了免疫组织学研究。在所有细胞构筑层中均发现了P物质、甲硫氨酸脑啡肽、亮氨酸脑啡肽和胆囊收缩素阳性纤维，每种肽都有特定的分布模式。生长抑素、催产素和血管加压素免疫反应仅限于特定的脊髓层。通过与先前的高尔基分析进行比较，观察并分类了神经元胞体和近端树突。P物质存在于III层的“放射状细胞”中，甲硫氨酸脑啡肽存在于边缘神经元以及II层的“星状细胞”中，生长抑素存在于II层的“胰岛细胞”中。一些结果与其他物种报道的不同。化学神经解剖学可能为人类脊髓的神经元组织提供新的见解。
