静脉注射6-羟基多巴胺对大鼠正中隆起和神经中间叶单胺含量的影响。

Effects of intravenously administered 6-hydroxydopamine on the content of monoamines in the median eminence and neurointermediate lobe of the rat.

作者信息

Sheward W J, Watts A G, Fink G, Smith G C

出版信息

Neurosci Lett. 1985 Apr 9;55(2):141-4. doi: 10.1016/0304-3940(85)90009-6.

Abstract

The effects of intravenous administration of 6-hydroxydopamine (6-OHDA) on the content of catecholamines in the median eminence and neurointermediate lobe was studied in male rats. The results confirmed previous findings of a depletion of catecholamines in both regions as a result of this lesion, although the magnitude of the effect was less than that revealed by fluorescence histochemistry. Administration of desipramine before 6-OHDA injection produced a more specific lesion, depleting dopamine but leaving noradrenaline unaffected.

摘要

在雄性大鼠中研究了静脉注射6-羟基多巴胺（6-OHDA）对正中隆起和神经中间叶中儿茶酚胺含量的影响。结果证实了先前的发现，即由于这种损伤，两个区域的儿茶酚胺均会耗竭，尽管其作用程度小于荧光组织化学所显示的程度。在注射6-OHDA之前给予地昔帕明会产生更特异性的损伤，使多巴胺耗竭，但去甲肾上腺素不受影响。