6-羟基多巴胺诱导大鼠垂体神经支配发生退行性变化。

6-Hydroxydopamine induces degenerative changes in innervation of the rat pituitary gland.

作者信息

Saland L C, Comunas F

出版信息

Neurosci Lett. 1985 Jun 4;57(1):49-55. doi: 10.1016/0304-3940(85)90039-4.

DOI:10.1016/0304-3940(85)90039-4

Abstract

Administration of 6-hydroxydopamine to adult male rats by peripheral injections induces degenerative changes in nerve terminals innervating cells of the pituitary intermediate lobe. Additional animals were treated with 5-hydroxydopamine, which produced images of nerve profiles containing vesicles with electron-dense centers, indicative of uptake of the false catecholamine (CA) neurotransmitter. Endocrine cells showed cytologic evidence of activation of synthetic and secretory compartments. The ultrastructural observations suggest that innervation to opiomelanocortin cells is sensitive to a CA-specific neurotoxin and strengthens the hypothesis that CA-containing fibers play a role in intermediate lobe neuroregulation.

摘要

通过外周注射向成年雄性大鼠施用6-羟基多巴胺会诱导支配垂体中间叶细胞的神经末梢发生退行性变化。另外一些动物用5-羟基多巴胺进行处理，这产生了含有中心电子致密的囊泡的神经轮廓图像，表明摄取了假儿茶酚胺（CA）神经递质。内分泌细胞显示出合成和分泌区室激活的细胞学证据。超微结构观察表明，阿片黑素皮质素细胞的神经支配对CA特异性神经毒素敏感，并强化了含CA纤维在中间叶神经调节中起作用的假说。

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