Mil'to I V
Morfologiia. 2014;146(5):40-5.
Using the immunohistochemical method, mononuclear phagocytes (MNPs) were detected in the liver, lung, kidneys and spleen of rats after a single intravenous injection of a suspension of magnetoliposomes and magnetic microspheres prepared on the basis of nanoscale magnetite particles of (NMPs). The dynamics of the of the number and topography of CD68(+)- and CD163(+)-cells in liver, lung and kidneys was characterized during 120 days after the intravenous injection of the suspension of modified NMPs. It was shown that NMPs surface modification reduced the degree and duration of macrophage activation. Signs of MNPs activation after the infusion of nanomaterial decreased in the following series: unmodified NMPs, magnetoliposomes, magnetic microspheres.
采用免疫组织化学方法，在大鼠单次静脉注射基于纳米级磁铁矿颗粒（NMPs）制备的磁脂质体和磁性微球悬浮液后，检测其肝脏、肺、肾脏和脾脏中的单核吞噬细胞（MNP）。在静脉注射修饰后的NMPs悬浮液后的120天内，对肝脏、肺和肾脏中CD68(+)和CD163(+)细胞的数量和分布动态进行了表征。结果表明，NMPs表面修饰降低了巨噬细胞激活的程度和持续时间。纳米材料注入后MNP激活的迹象在以下序列中减少：未修饰的NMPs、磁脂质体、磁性微球。
