Christo Susan N, Diener Kerrilyn R, Hayball John D
Experimental Therapeutics Laboratory, Sansom Institute and Hanson Institute, School of Pharmacy and Medical Science, Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Robinson Research Institute, School of Paediatrics and Reproductive Health, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Immunol Cell Biol. 2015 Sep;93(8):694-704. doi: 10.1038/icb.2015.34. Epub 2015 Mar 31.
The role of intracellular calcium ion oscillations in T-cell physiology is being increasingly appreciated by studies that describe how unique temporal and spatial calcium ion signatures can control different signalling pathways. Within this review, we provide detailed mechanisms of calcium ion oscillations, and emphasise the pivotal role that calcium signalling plays in directing crucial events pertaining to T-cell functionality. We also describe methods of calcium ion quantification, and take the opportunity to discuss how a deeper understanding of calcium signalling combined with new detection and quantification methodologies can be used to better design immunotherapies targeting T-cell responses.
细胞内钙离子振荡在T细胞生理学中的作用正日益受到研究的重视，这些研究描述了独特的时空钙离子信号如何控制不同的信号通路。在本综述中，我们提供了钙离子振荡的详细机制，并强调了钙信号在指导与T细胞功能相关的关键事件中所起的关键作用。我们还描述了钙离子定量的方法，并借此讨论如何将对钙信号的更深入理解与新的检测和定量方法相结合，以更好地设计针对T细胞反应的免疫疗法。
