Vaidya Varun, Gangan Nilesh, Sheehan Jack
Department of Pharmacy Practice, Pharmacy Health Care Administration, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Health Science Campus 3000 Arlington Ave., Toledo, OH 43614, USA.
Expert Rev Pharmacoecon Outcomes Res. 2015 Jun;15(3):487-97. doi: 10.1586/14737167.2015.1024661. Epub 2015 Mar 31.
Macrovascular and microvascular complications that accompany Type 2 diabetes mellitus (T2DM) add to the burden among patients. The purpose of this systematic review is to conduct a comprehensive search of the medical literature investigating the prevalence of cardiovascular (CV) complications and assess their impact on healthcare costs, quality of life and mortality among patients with T2DM in the context of microvascular complications. A total of 76 studies and reports were used in this systematic review. Hypertension was the most prevalent complication among patients with T2DM. The additional cost burden due to CV complications was higher than any other complication except end-stage renal disease. Quality of life was much lower among patients with CV complications and T2DM, and mortality was higher than either illness alone.
2型糖尿病（T2DM）所伴随的大血管和微血管并发症增加了患者的负担。本系统评价的目的是全面检索医学文献，调查心血管（CV）并发症的患病率，并在微血管并发症的背景下评估其对T2DM患者医疗费用、生活质量和死亡率的影响。本系统评价共纳入了76项研究和报告。高血压是T2DM患者中最常见的并发症。除终末期肾病外，CV并发症导致的额外费用负担高于任何其他并发症。CV并发症合并T2DM的患者生活质量低得多，死亡率也高于单独患这两种疾病中的任何一种。
