Khmaladze Ia, Nandakumar Kutty Selva, Holmdahl Rikard
Division of Medical Inflammation Research, Department of Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Int Arch Allergy Immunol. 2015;166(2):135-49. doi: 10.1159/000375401. Epub 2015 Mar 20.
Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26%) develop inflammatory disease in other organs, often in the joints as in psoriasis arthritis (PsA). Animal models that reflect the typical Ps syndrome, including both skin and joint pathology as in Ps and PsA, are valuable tools for dissecting disease pathways leading to clinical manifestations. In this context, we developed a new acute Ps and PsA-like disease model that appears after exposure to Saccharomyces cerevisiae mannan in certain mouse strains. The disease was found to be triggered by mannan-activated macrophages, leading to the activation of a pathogenic interleukin-17 pathway involving innate lymphocytes. Interestingly, the production of reactive oxygen species protected the mice from the triggering of this pathway and ameliorated Ps and PsA development.
银屑病（Ps）是一种慢性、免疫介导的皮肤炎症性疾病，全球高达3%的人口受其影响。不同的环境诱因引发了这种复杂的多因素综合征。许多银屑病患者（6%-26%）会在其他器官出现炎症性疾病，通常是在关节部位，如银屑病关节炎（PsA）。能够反映典型银屑病综合征（包括银屑病和银屑病关节炎中的皮肤和关节病理）的动物模型，是剖析导致临床表现的疾病途径的宝贵工具。在此背景下，我们开发了一种新的急性银屑病和银屑病关节炎样疾病模型，该模型在特定小鼠品系暴露于酿酒酵母甘露聚糖后出现。发现该疾病由甘露聚糖激活的巨噬细胞触发，导致涉及固有淋巴细胞的致病性白细胞介素-17途径的激活。有趣的是，活性氧的产生保护小鼠免受该途径的触发，并改善了银屑病和银屑病关节炎的发展。
