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[高剂量阿糖胞苷强化缓解后治疗急性髓系白血病]

[Intensive post-remission therapy of acute myeloid leukemia with high doses of cytosine arabinoside].

作者信息

Slechtová J, Koza V, Svojgrová M, Cepelák V

出版信息

Cas Lek Cesk. 1989 Sep 22;128(39):1239-42.

PMID:2582468
Abstract

The results are estimated of treatment for acute myeloid leukaemia using intensive post-remission therapy with high doses of cytosine arabinoside (HiDAC). Two women and four men aged 18-34 years were treated with HiDAC. None of them had been given maintenance or boost chemotherapy any more at the time. The patients were rated for the duration of granulocytopenia and thrombocytopenia for the incidence of non-haematological complications and for the duration and quality of survival. The preliminary results are promising and in keeping with those reported by similar clinical centres abroad, namely that maintenance therapy should be phased out in the presence of intensive post-remission treatment.

摘要

评估了使用大剂量阿糖胞苷(HiDAC)进行强化缓解后治疗急性髓系白血病的效果。两名女性和四名年龄在18至34岁之间的男性接受了HiDAC治疗。当时他们均未再接受维持或强化化疗。对患者的粒细胞减少症和血小板减少症持续时间、非血液学并发症发生率以及生存持续时间和质量进行了评估。初步结果令人鼓舞,与国外类似临床中心报告的结果一致,即在存在强化缓解后治疗的情况下应逐步淘汰维持治疗。

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