Xu Dong-Wei, Zhang Guan-Qing, Wang Zong-Wei, Xu Xiao-Yin, Liu Tong-Xiang
Department of Chinese Minority Traditional Medicine, Minzu University of China, Beijing, China E-mail :
Asian Pac J Cancer Prev. 2015;16(6):2167-75. doi: 10.7314/apjcp.2015.16.6.2167.
Autophagy is a self-digestion process, wrapping cytoplasmic proteins or organelles to form vesicles for degradation in lysosomes. The process plays an important role in the maintenance of intracellular homostasis. Here we overview articles on autophagy and cancer/tumors in Pubmed and found 327 articles. Autophagy exists in many tumors and is involved in cell malignant transformation and tumor cell growth. In early phases of tumorigenesis, autophagy clears the abnormally folded proteins and dysfunctional organelles such as mitochondria. Autophagy can also inhibit cell stress responses and prevent genetic damage. When a tumor develops, autophagy helps tumor cells survive nutritional deficiencies and hypoxic conditions. Studies of autophagy in the occurrence and progression of tumors should provide new therapeutic strategies for tumors.
自噬是一种自我消化过程，它包裹细胞质蛋白或细胞器以形成囊泡，在溶酶体中进行降解。该过程在维持细胞内稳态方面发挥着重要作用。我们在此概述了在PubMed上有关自噬与癌症/肿瘤的文章，共找到327篇文章。自噬存在于许多肿瘤中，并参与细胞恶性转化和肿瘤细胞生长。在肿瘤发生的早期阶段，自噬清除异常折叠的蛋白质和功能失调的细胞器，如线粒体。自噬还可以抑制细胞应激反应并防止遗传损伤。当肿瘤发展时，自噬帮助肿瘤细胞在营养缺乏和缺氧条件下存活。对肿瘤发生和进展过程中自噬的研究应为肿瘤提供新的治疗策略。
