Baykan Halit, Cihan Yasemin Benderli, Ozyurt Kemal
Department of Plastic and Reconstructive Surgery, Kayseri Education and Research Hospital, Kayseri, Turkey E-mail :
Asian Pac J Cancer Prev. 2015;16(6):2303-6. doi: 10.7314/apjcp.2015.16.6.2303.
Skin tumors are the most commonly seen cancer type worldwide. Regarding pathogenesis, it is thought that disruption of kinetics through T lymphocyte-mediated development of chronic inflammation may be involved. The present study was intended to identify role of inflammatory cells such as neutrophils, monocytes and lymphocytes in the determination of risk for skin cancer.
We retrospectively reviewed charts of 569 cases diagnosed as having primary skin tumors. Data regarding age, gender and histopathological subtype were recorded. Blood parameters studied on the day before surgery including WBCs, neutrophils, and lymphocyte counts, neutrophil:lymphocyte and neutrophil:monocyte ratios were also recorded. Two-hundred and two healthy individuals presented for check-up in an outpatient clinic were selected as the control group. Parameters studied in cases with skin cancer were compared to those healthy individuals.
Of the cases with skin cancer, 401 were basal cell carcinoma (BCC) while 144 were squamous cell carcinoma (SCC) and 13 were malignant melanoma (MM). WBC, neutrophil and monocyte counts and the neutrophil:lymphocyte ratio were found to be lower in the patient group than in the healthy control group (p<0.001) while no significant difference was found in other parameters reviewed (p>0.05). No significant difference was found in WBC, neutrophil, neutrophil: monocyte ratio according to gender (p>0.05). Monocyte count was found to be 0.68±0.61 in men and 0.55±0.25 in women, indicating strong statistical significance (p<0.001). WBC, neutrophil and monocyte values were highest in control group while lowest in BCC. When BCC and SCC groups were compared to controls, significant differences found (p<0.001). There were no significant differences in lymphocyte counts among groups (p=0.976). Neutrophil:lymphocyte ratios were 3.24 in BCC, 3.59 in SCC, 3.44 in MM and 5.06 in control group (p<0.001).
In our study, it was found that there were significant differences in complete blood count, neutrophil, monocyte and neutrophil:lymphocyte levels among groups. Neutrophil: lymphocyte ratio was found to be lowest in BCC among skin cancers.
皮肤肿瘤是全球最常见的癌症类型。关于其发病机制，人们认为通过T淋巴细胞介导的慢性炎症发展导致的动力学破坏可能与之有关。本研究旨在确定中性粒细胞、单核细胞和淋巴细胞等炎症细胞在皮肤癌风险判定中的作用。
我们回顾性分析了569例诊断为原发性皮肤肿瘤患者的病历。记录了年龄、性别和组织病理学亚型等数据。还记录了手术前一天研究的血液参数，包括白细胞、中性粒细胞和淋巴细胞计数，以及中性粒细胞与淋巴细胞和中性粒细胞与单核细胞的比例。选择202名在门诊进行体检的健康个体作为对照组。将皮肤癌患者的参数与这些健康个体的参数进行比较。
在皮肤癌患者中，401例为基底细胞癌（BCC），144例为鳞状细胞癌（SCC），13例为恶性黑色素瘤（MM）。发现患者组的白细胞、中性粒细胞和单核细胞计数以及中性粒细胞与淋巴细胞的比例低于健康对照组（p<0.001），而在其他审查参数中未发现显著差异（p>0.05）。根据性别，白细胞、中性粒细胞、中性粒细胞与单核细胞的比例未发现显著差异（p>0.05）。男性单核细胞计数为0.68±0.61，女性为0.55±0.25，具有很强的统计学意义（p<0.001）。白细胞、中性粒细胞和单核细胞值在对照组中最高，在BCC组中最低。当将BCC组和SCC组与对照组进行比较时，发现有显著差异（p<0.001）。各组间淋巴细胞计数无显著差异（p=0.976）。BCC组中性粒细胞与淋巴细胞的比例为3.24，SCC组为3.59，MM组为3.44，对照组为5.06（p<0.001）。
在我们的研究中，发现各组间全血细胞计数、中性粒细胞、单核细胞和中性粒细胞与淋巴细胞水平存在显著差异。在皮肤癌中，BCC组的中性粒细胞与淋巴细胞比例最低。
