Department of Neurosurgery, XinHua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200092, China.
Department of Neurosurgery, Fujian Provincial Hospital, Fuzhou, Fujian, China.
J Neurooncol. 2018 May;138(1):113-122. doi: 10.1007/s11060-018-2776-x. Epub 2018 Jan 31.
To compare the different levels of preoperative inflammatory markers in peripheral blood samples between craniopharyngioma (CP) and other sellar region tumors so as to explore their differential diagnostic value. The level of white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet, albumin, neutrophil lymphocyte ratio (NLR), derived NLR (dNLR), platelet lymphocyte ratio (PLR), monocyte lymphocyte ratio (MLR) and prognostic nutritional index (PNI) were compared between the CP and other sellar region tumors. A receiver operating characteristics (ROC) curve analysis was performed to evaluate the diagnostic significance of the peripheral blood inflammatory markers and their paired combinations for CP including its pathological types. Patients with CP had higher levels of pre-operative WBC, lymphocyte and PNI. The papillary craniopharyngioma (PCP) group had higher neutrophil count and NLR than the adamantinomatous craniopharyngioma (ACP) and healthy control groups whereas the ACP group had higher platelet count and PNI than the PCP and healthy control groups. There were not any significant differences in preoperative inflammatory markers between the primary and recurrent CP groups. The AUC values of WBC, neutrophil, NLR + PLR and dNLR + PLR in PCP were all higher than 0.7. Inflammation seems to be closely correlated with CP's development. The preoperative inflammatory markers including WBC, neutrophil, NLR + PLR and dNLR + PLR may differentially diagnose PCP, pituitary tumor (PT) and Rathke cleft cyst (RCC). In addition, some statistical results in this study indirectly proved previous experimental conclusions and strictly matched CP's biological features.
为了比较颅咽管瘤（CP）和其他鞍区肿瘤外周血样本中术前炎症标志物的水平，以探讨其鉴别诊断价值。比较 CP 和其他鞍区肿瘤患者外周血白细胞（WBC）、中性粒细胞、淋巴细胞、单核细胞、血小板、白蛋白、中性粒细胞与淋巴细胞比值（NLR）、衍生 NLR（dNLR）、血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）和预后营养指数（PNI）的水平。通过受试者工作特征（ROC）曲线分析评估外周血炎症标志物及其配对组合对 CP 及其病理类型的诊断意义。CP 患者术前 WBC、淋巴细胞和 PNI 水平较高。与 CP 中其他病理类型相比，乳头型颅咽管瘤（PCP）组的中性粒细胞计数和 NLR 较高，而腺瘤型颅咽管瘤（ACP）组的血小板计数和 PNI 较高。初发和复发 CP 组术前炎症标志物无显著差异。WBC、中性粒细胞、NLR+PLR 和 dNLR+PLR 在 PCP 中的 AUC 值均高于 0.7。炎症似乎与 CP 的发展密切相关。术前炎症标志物包括 WBC、中性粒细胞、NLR+PLR 和 dNLR+PLR 可能有助于鉴别诊断 PCP、垂体瘤（PT）和 Rathke 裂囊肿（RCC）。此外，本研究中的一些统计结果间接证明了先前的实验结论，并严格符合 CP 的生物学特征。
