Yin Y X
Zhonghua Bing Li Xue Za Zhi. 1989 Jun;18(2):125-7.
Through immunohistochemical technique, distribution of FN in normal mucosa, benign and malignant tumors of human gastrointestinal tract were studied. In normal and adenoma tissues, FN was found in both basement membrane (BN) and interstitial tissue. While in cancer tissue, there was a consistent decrease of BM FN content around the tumor nests particularly more apparently in cases of invading carcinoma. Statistical analysis showed that the reduction of BM FN was correlated with the degree of tumor dedifferentiation but not with the incidence of regional metastases. No association was noticed between the stroma FN and tumor behaviors. Since small blood vessels were usually delineated clearly by the staining for FN, FN might be considered as a marker in identifying the invasion of blood vessel wall by tumor cells. It is suggested that lack of BM FN in tumor tissues might be mainly due to decrease of FN synthesis by the tumor cells.
通过免疫组织化学技术，研究了纤维连接蛋白（FN）在人胃肠道正常黏膜、良性肿瘤和恶性肿瘤中的分布。在正常组织和腺瘤组织中，在基底膜（BN）和间质组织中均发现了FN。而在癌组织中，肿瘤巢周围的基底膜FN含量持续降低，尤其是在浸润性癌病例中更为明显。统计分析表明，基底膜FN的减少与肿瘤去分化程度相关，但与区域转移发生率无关。未发现间质FN与肿瘤行为之间存在关联。由于FN染色通常能清晰勾勒出小血管，因此FN可被视为识别肿瘤细胞侵袭血管壁的标志物。提示肿瘤组织中基底膜FN的缺乏可能主要是由于肿瘤细胞FN合成减少所致。
