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胃肠道和唾液腺上皮性肿瘤中的纤连蛋白和III型胶原蛋白。

Fibronectin and type III collagen in epithelial neoplasms of gastrointestinal tract and salivary gland.

作者信息

D'Ardenne A J, Burns J, Sykes B C, Bennett M K

出版信息

J Clin Pathol. 1983 Jul;36(7):756-63. doi: 10.1136/jcp.36.7.756.

DOI:10.1136/jcp.36.7.756
PMID:6863567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC498383/
Abstract

The distribution of fibronectin (FN) and collagen type III (IIIC) have been compared in a series of epithelial neoplasms from the gastrointestinal tract and salivary gland. The difficulty of distinguishing between FN of epithelial and fibroblastic origin is emphasised and evidence is presented for the validity of this distinction. In carcinomas FN was sometimes, but not invariably, lost from epithelial cell surfaces. Both FN and IIIC were increased in reactive connective tissue stroma. It is concluded that loss of cell surface FN is unlikely to be a useful diagnostic marker for malignancy, but that the occurrence of this phenomenon in vivo as in vitro indicates that it is biologically significant.

摘要

在一系列来自胃肠道和唾液腺的上皮性肿瘤中，对纤连蛋白（FN）和III型胶原（IIIC）的分布进行了比较。强调了区分上皮来源和纤维母细胞来源的FN的困难，并提供了这种区分有效性的证据。在癌中，FN有时但并非总是从上皮细胞表面丢失。FN和IIIC在反应性结缔组织基质中均增加。结论是，细胞表面FN的丢失不太可能是恶性肿瘤的有用诊断标志物，但这种现象在体内和体外的发生表明它具有生物学意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/90f4af590db5/jclinpath00512-0039-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/a652df1fab57/jclinpath00512-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/5daea033af57/jclinpath00512-0036-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/081596fabb85/jclinpath00512-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/db3f38d9f714/jclinpath00512-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/5b9d50dda0ee/jclinpath00512-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/895d8a6cccb3/jclinpath00512-0038-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/2acd74e3c946/jclinpath00512-0038-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/90f4af590db5/jclinpath00512-0039-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/a652df1fab57/jclinpath00512-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/5daea033af57/jclinpath00512-0036-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/081596fabb85/jclinpath00512-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/db3f38d9f714/jclinpath00512-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/5b9d50dda0ee/jclinpath00512-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/895d8a6cccb3/jclinpath00512-0038-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/2acd74e3c946/jclinpath00512-0038-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c2/498383/90f4af590db5/jclinpath00512-0039-a.jpg

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本文引用的文献

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ULTRASTRUCTURE OF ADENOMATOUS POLYPS AND VILLOUS ADENOMAS OF THE LARGE INTESTINE.大肠腺瘤性息肉和绒毛状腺瘤的超微结构
Gastroenterology. 1965 Feb;48:188-97.
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Ultrastructure of adenocarcinoma of the colon.结肠腺癌的超微结构
Gastroenterology. 1963 Apr;44:410-8.
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The effect of human fibronectin on platelet-collagen adhesion.人纤连蛋白对血小板-胶原蛋白黏附的影响。
J Clin Pathol. 1984 Jun;37(6):639-44. doi: 10.1136/jcp.37.6.639.
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Distribution of laminin, fibronectin, and interstitial collagen type III in soft tissue tumours.层粘连蛋白、纤连蛋白和III型间质胶原在软组织肿瘤中的分布
J Clin Pathol. 1984 Aug;37(8):895-904. doi: 10.1136/jcp.37.8.895.
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Laminin and fibronectin in adenoid cystic carcinoma.腺样囊性癌中的层粘连蛋白和纤连蛋白。
J Clin Pathol. 1986 Feb;39(2):138-44. doi: 10.1136/jcp.39.2.138.
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Use of basement membrane markers in tumour diagnosis.基底膜标志物在肿瘤诊断中的应用。
J Clin Pathol. 1989 May;42(5):449-57. doi: 10.1136/jcp.42.5.449.
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Characterisation of adenoid cystic carcinoma of the breast by immunohistology.乳腺腺样囊性癌的免疫组织学特征
J Clin Pathol. 1989 May;42(5):470-6. doi: 10.1136/jcp.42.5.470.
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Virchows Arch A Pathol Anat Histopathol. 1989;415(2):137-44. doi: 10.1007/BF00784351.
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Lack of correlation between metastasis of human rectal carcinoma and the absence of stromal fibronectin.人直肠癌转移与基质纤连蛋白缺失之间缺乏相关性。
Br J Cancer. 1982 Apr;45(4):500-5. doi: 10.1038/bjc.1982.85.
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