Liu K F
Zhonghua Bing Li Xue Za Zhi. 1989 Jun;18(2):89-91.
Phenotypes of the tumor cells of malignant histiocytosis (MH) were studied by using monoclonal and polyclonal antibodies in 18 autopsy cases. The tumor cells expressed different antigens in various degrees. Almost all tumor cells showed positive reaction for alpha 1-ACT; partially for alpha 1-AT, LCA and a few for lysozyme as well as LeuM1. It was most likely that the tumor cells of MH originated from the mononuclear phagocytic system (MPS). In order to reveal the relationship between MH and immunodeficiency, morphological changes of the lympho-reticular system in 18 cases of MH were studied. It was found that the lymphoid tissues, including lymph nodes, thymus, tonsil, spleen, bone marrow, lymphoid tissues of GI tract and lung etc showed severe depletion. These findings indicate that MH usually combine with immunodeficiency which is also closely related to the pathogenesis and pathological changes of MH.
应用单克隆及多克隆抗体，对18例恶性组织细胞病（MH）尸检病例的肿瘤细胞表型进行了研究。肿瘤细胞不同程度地表达多种抗原。几乎所有肿瘤细胞α1-抗糜蛋白酶（α1-ACT）呈阳性反应；部分α1-抗胰蛋白酶（α1-AT）、白细胞共同抗原（LCA）阳性，少数病例溶菌酶及LeuM1阳性。MH的肿瘤细胞很可能起源于单核吞噬细胞系统（MPS）。为揭示MH与免疫缺陷的关系，对18例MH患者淋巴网状系统的形态学变化进行了研究。发现包括淋巴结、胸腺、扁桃体、脾脏、骨髓、胃肠道及肺等部位的淋巴组织均有严重耗竭。这些结果表明，MH常合并免疫缺陷，且免疫缺陷与MH的发病机制及病理变化密切相关。
