Barclay G R, Scott B B, Wright I H, Rogers P N, Smith D G, Poxton I R
S.E. Scotland Regional Blood Transfusion Centre, Royal Infirmary, Edinburgh, UK.
Circ Shock. 1989 Oct;29(2):93-106.
Circulating endotoxin levels and IgG antibodies to a range of Gram-negative bacterial lipopolysaccharides (LPS) (endotoxins) of different sizes and structures were measured daily in three cases of septic shock. There was an inverse relationship between endotoxin levels and cross-reactive antibodies to the core glycolipid (CGL) region of lipopolysaccharide. This suggests that antibody to LPS-CGL was initially consumed by a superabundance of endotoxin, and that a resurgence of intrinsic anti-LPS-CGL antibody levels may be associated with a reduction of circulating endotoxin. The implications of these findings for passive antibody therapy of septic shock are discussed.
在三例感染性休克患者中，每天测量循环内毒素水平以及针对一系列不同大小和结构的革兰氏阴性菌脂多糖（LPS，即内毒素）的IgG抗体。内毒素水平与针对脂多糖核心糖脂（CGL）区域的交叉反应抗体之间存在负相关关系。这表明LPS-CGL抗体最初被过量的内毒素消耗，并且内源性抗LPS-CGL抗体水平的回升可能与循环内毒素的减少有关。本文讨论了这些发现对感染性休克被动抗体治疗的意义。
