酒精性胰腺炎：烈酒与细菌的故事。
Alcoholic pancreatitis: A tale of spirits and bacteria.
作者信息
Vonlaufen Alain, Spahr Laurent, Apte Minoti V, Frossard Jean-Louis
机构信息
Alain Vonlaufen, Gastroenterology Unit, Hôpital de la Tour, 1217 Meyrin/Genève, Switzerland.
出版信息
World J Gastrointest Pathophysiol. 2014 May 15;5(2):82-90. doi: 10.4291/wjgp.v5.i2.82.
Abstract
Alcohol is a major cause of chronic pancreatitis. About 5% of alcoholics will ever suffer from pancreatitis, suggesting that additional co-factors are required to trigger an overt disease. Experimental work has implicated lipopolysaccharide, from gut-derived bacteria, as a potential co-factor of alcoholic pancreatitis. This review discusses the effects of alcohol on the gut flora, the gut barrier, the liver-and the pancreas and proposes potential interventional strategies. A better understanding of the interaction between the gut, the liver and the pancreas may provide valuable insight into the pathophysiology of alcoholic pancreatitis.
摘要
酒精是慢性胰腺炎的主要病因。约5%的酗酒者会患上胰腺炎，这表明引发明显疾病还需要其他共同因素。实验研究表明，来自肠道细菌的脂多糖可能是酒精性胰腺炎的潜在共同因素。本文综述了酒精对肠道菌群、肠道屏障、肝脏和胰腺的影响，并提出了潜在的干预策略。更好地理解肠道、肝脏和胰腺之间的相互作用，可能为酒精性胰腺炎的病理生理学提供有价值的见解。
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