Org Lett. 2015 Apr 17;17(8):1974-7. doi: 10.1021/acs.orglett.5b00722. Epub 2015 Mar 31.
An I2/CHP-mediated cross-coupling reaction of isocyanides with readily accessible amines via C-N formation is described for carbodiimide synthesis in moderate to excellent yields. This represents a metal-free strategy for a coupling reaction of isocyanides with amines, and it provides an efficient approach for symmetric and unsymmetric functionalized carbodiimide derivative synthesis under mild conditions.
描述了一种通过 C-N 形成的异氰化物与易得胺之间的 I2/CHP 介导的交叉偶联反应，用于中等至优异收率的碳二亚胺合成。这代表了一种无金属的异氰化物与胺的偶联反应策略，为在温和条件下合成对称和非对称官能化的碳二亚胺衍生物提供了一种有效方法。
