Zhang Zhen, Li Zongyang, Fu Bin, Zhang Zhenhua
Department of Applied Chemistry, China Agricultural University, West Yuanmingyuan Rd. 2, Beijing 100193, People's Repubic of China.
Chem Commun (Camb). 2015 Nov 25;51(91):16312-5. doi: 10.1039/c5cc05981j.
An efficient palladium-catalyzed cross-coupling reaction of azides with isocyanides is developed, providing a general synthetic route to unsymmetric carbodiimides with excellent yields. This method shows a broad substrate scope, including not only aryl azides, but also unactivated benzyl and alkyl azides. Furthermore, from readily available substrates, Pd-catalyzed coupling with a tandem amine insertion cascade to obtain unsymmetric trisubstituted guanidines has been achieved in a one-pot fashion.
开发了一种高效的钯催化叠氮化物与异腈的交叉偶联反应，为合成不对称碳二亚胺提供了一条通用的合成路线，产率优异。该方法具有广泛的底物范围，不仅包括芳基叠氮化物，还包括未活化的苄基和烷基叠氮化物。此外，以一锅法实现了从易得的底物出发，通过钯催化的偶联与串联胺插入级联反应来获得不对称三取代胍。
