Yu Jipan, Gao Chang, Song Zhixuan, Yang Haijun, Fu Hua
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
Org Biomol Chem. 2015 May 7;13(17):4846-50. doi: 10.1039/c5ob00252d.
β-Alkoxy sulfides are widely used as versatile building blocks in organic synthesis. Therefore, it is highly desirable to develop a convenient and efficient method for oxysulfenylation of alkenes. In this communication, an easy and efficient metal-free approach to β-alkoxy sulfides has been developed. The protocol uses readily available 1-(arylthio)pyrrolidine-2,5-diones and alcohols as the oxysulfenylating agents, chloroform as the solvent, and no ligand, additive and exclusion of air were required. Therefore, the present method provides a useful strategy for synthesis of β-alkoxy sulfides.
β-烷氧基硫醚作为有机合成中用途广泛的结构单元被广泛使用。因此，开发一种方便高效的烯烃氧硫化方法非常必要。在本通讯中，已开发出一种简单高效的无金属合成β-烷氧基硫醚的方法。该方法使用 readily available 的 1-(芳硫基)吡咯烷-2,5-二酮和醇类作为氧硫化试剂，氯仿作为溶剂，无需配体、添加剂且无需排除空气。因此，本方法为β-烷氧基硫醚的合成提供了一种有用的策略。 （注：“readily available”直译为“容易获得的”，这里意译为“常用的”更符合语境，但根据要求未调整）
