Rodger M W, Baird D T
University of Edinburgh, Department of Obstetrics & Gynaecology, UK.
Contraception. 1989 Oct;40(4):439-47. doi: 10.1016/0010-7824(89)90051-6.
The pattern and amount of blood loss following induction of therapeutic abortion using mifepristone (RU 486) and a prostaglandin E analogue (gemeprost) was studied in 222 women of less than 63 days amenorrhoea. A single oral dose of mifepristone (400, 500 or 600 mg) was followed 48 hours later by a half or 1 mg gemeprost vaginal pessary. Complete abortion occurred in 218 (98%) women without necessity for surgical evacuation of the uterus. Bleeding commonly occurred following administration of mifepristone and prior to prostaglandin administration. The median duration of bleeding following abortion was 13 days with a range of from 1 to 44 days. There was a wide individual variation in measured blood loss between women, from 14 to 512 ml, with a median loss of 74 ml. The amount of blood loss was independent of the dose of mifepristone or prostaglandin but was significantly correlated with gestation. These results confirm that the combination of mifepristone and gemeprost is a highly effective and safe method of inducing therapeutic abortion medically. As the amount of blood loss increases with increasing gestation, it is suggested that its use should be restricted to women with amenorrhoea less than or equal to 56 days.
对222名闭经时间少于63天的女性，研究了使用米非司酮（RU 486）和前列腺素E类似物（吉美前列素）进行治疗性流产后的失血模式和失血量。单次口服米非司酮（400、500或600毫克），48小时后阴道置入半片或1毫克吉美前列素栓剂。218名（98%）女性发生完全流产，无需进行子宫手术排空。出血通常在服用米非司酮后、给予前列腺素之前出现。流产后出血的中位持续时间为13天，范围为1至44天。女性之间测量的失血量个体差异很大，从14至512毫升，中位失血量为74毫升。失血量与米非司酮或前列腺素的剂量无关，但与孕周显著相关。这些结果证实，米非司酮和吉美前列素联合使用是一种高效且安全的药物性治疗性流产方法。由于失血量随孕周增加而增加，建议其使用应限于闭经时间小于或等于56天的女性。
