Department for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chia-Yi 61363, Taiwan.
Department for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chia-Yi 61363, Taiwan; Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei 10055, Taiwan.
J Ethnopharmacol. 2015 Jun 20;168:129-35. doi: 10.1016/j.jep.2015.03.047. Epub 2015 Mar 28.
ETHNO-PHARMACOLOGICAL RELEVANCE: Chinese herbal products (CHPs) are commonly used in patients with hyperlipidemia in traditional Chinese medicine (TCM). Because hyperlipidemia and related disease are common issues worldwide, this study analyzed the prescription patterns and frequencies of CHPs for treating patients with hyperlipidemia in Taiwan.
Traditional Chinese medicine (TCM) has become popular as a therapy for controlling symptoms in patients with hyperlipidemia. This study aimed to analyze the prescription patterns of TCM for patients with hyperlipidemia in Taiwan.
The study population was recruited from a random-sampled cohort of 1,000,000 people from the National Health Insurance Research Database between 2003 and 2009. We identified 30,784 outpatient visits related with hyperlipidemia diagnosis and collected these medical records. Association rules of data mining were conducted to explore the co-prescription patterns for Chinese herbal products (CHPs).
The most commonly prescribed herbal formula for hyperlipidemia treatment was Xue-Fu-Zhu-Yu-Tang (16.1%), and Shan Zha (Crataegi fructus; 25.0%) was the most commonly prescribed single herb. The most commonly prescribed combination of an herbal formula and a single herb was Xue-Fu-Zhu-Yu-Tang and Dan Shen (Radix Salviae Miltiorrhizae), and the most commonly prescribed combination of couplet herbs was Dan Shen and Shan Zha.
Xue-Fu-Zhu-Yu-Tang is the most frequently prescribed formula and is typically prescribed with Shan Zha, Dan Shen, and He Shou Wu for patients with hyperlipidemia. Clinical trials are warranted in future research to investigate the effects of the CHPs in terms of safety and efficacy and in particular to evaluate potential interactions with conventional treatments.
中草药产品（CHPs）在中医药治疗高血脂患者中被广泛使用。由于高血脂和相关疾病在全球范围内普遍存在，因此本研究分析了台湾地区治疗高血脂患者的 CHP 处方模式和频率。
中医药（TCM）已成为控制高血脂患者症状的热门疗法。本研究旨在分析台湾地区高血脂患者的 TCM 处方模式。
本研究的研究对象是从 2003 年至 2009 年国家健康保险研究数据库中随机抽样的 100 万人的门诊患者中招募的。我们确定了 30784 次与高血脂诊断相关的门诊就诊，并收集了这些病历。通过数据挖掘关联规则来探讨中草药（CHPs）的联合用药模式。
治疗高血脂最常用的草药方剂是血府逐瘀汤（16.1%），最常用的单味草药是山楂（25.0%）。最常用的草药方剂和单味草药组合是血府逐瘀汤和丹参（丹参），最常用的草药组合是丹参和山楂。
血府逐瘀汤是最常用的方剂，通常与山楂、丹参和何首乌一起用于治疗高血脂患者。未来的研究需要进行临床试验，以评估 CHPs 在安全性和疗效方面的效果，特别是评估与常规治疗的潜在相互作用。
