Tsai Ming-Yen, Hu Wen-Long, Lin Che-Chen, Lee Yi-Chiao, Chen Shih-Yu, Hung Yu-Chiang, Chen Yung-Hsiang
Graduate Institute of Integrated Medicine, College of Chinese Medicine, Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung, Taiwan; Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Int J Cardiol. 2017 Feb 1;228:90-96. doi: 10.1016/j.ijcard.2016.11.172. Epub 2016 Nov 9.
Certain Chinese herbal products (CHPs) may protect against the progression of heart failure (HF). However, there is a lack of research regarding the use of CHPs in patients with HF. The aims of this study were to analyze CHPs usage patterns in patients with HF and to identify the frequency and combination of CHPs most commonly used for HF.
This retrospective, nationwide, population-based cohort study was conducted using a randomly sampled cohort of one million patients selected from the National Health Insurance Research Database (NHIRD) for the years 2000-2010 in Taiwan. CHP use and the top ten most frequently prescribed formulae and single herbs for treating HF were assessed, including total formulae number and average and frequency of prescriptions. Demographic characteristics, including sex and age at diagnosis of HF, were examined, together with existing comorbidities.
The cohort included 19,988 newly diagnosed AD patients, who were given CHP treatment for HF between 2000 and 2010. Among them, female patients (53.3%) and those over 65years old (63.9%) were more likely to use CM. After adjusting for demographic factors, HF patients suffering from coronary artery disease (CAD) were more likely to seek traditional Chinese medicine (TCM) treatment than those with non-TCM users (57.6% vs. 52.6%). Zhi-Gan-Cao-Tang (4.07%) and Danshen (5.13%) were the most frequent formula CHP and single CHP prescribed by TCM practitioners for treating HF, respectively.
Most people with HF who consumed CHPs used CHPs to supplement Yang-Qi, nourish the Ying-blood, and strengthen the heart spirit as complementary medicines to relieve HF-related symptoms, in addition to using standard anti-HF treatments. Further large-scale, randomized clinical trials are warranted in order to determine the effectiveness and safety of these herbal medicines.
某些中药产品可能预防心力衰竭（HF）进展。然而，关于HF患者使用中药产品的研究较少。本研究旨在分析HF患者的中药产品使用模式，并确定最常用于HF的中药产品的使用频率和组合。
本回顾性、全国性、基于人群的队列研究使用从2000年至2010年台湾地区国民健康保险研究数据库（NHIRD）中随机抽取的100万患者队列。评估中药产品使用情况以及治疗HF最常用的十大方剂和单味中药，包括方剂总数以及处方的平均数和频率。检查人口统计学特征，包括HF诊断时的性别和年龄，以及现有的合并症。
该队列包括19988例新诊断的HF患者，他们在2000年至2010年期间接受了HF的中药产品治疗。其中，女性患者（53.3%）和65岁以上患者（63.9%）更有可能使用中药。在调整人口统计学因素后，患有冠状动脉疾病（CAD）的HF患者比未使用中药的患者更有可能寻求中医治疗（57.6%对52.6%）。炙甘草汤（4.07%）和丹参（5.13%）分别是中医师治疗HF最常用的方剂类中药产品和单味中药产品。
大多数服用中药产品的HF患者除了使用标准抗HF治疗外，还使用中药产品来补充阳气、滋养营血和振奋心神，作为缓解HF相关症状的补充药物。需要进一步进行大规模随机临床试验，以确定这些草药的有效性和安全性。
