Abraham E, Yoshihara G
Department of Medicine, UCLA Medical Center.
Chest. 1989 Dec;96(6):1356-9. doi: 10.1378/chest.96.6.1356.
Cardiorespiratory values were measured in nine patients with severe respiratory failure before and following initiation of pressure controlled inverse ratio ventilation (PC-IRV) at an inspiratory to expiratory ratio of 2:1. All patients showed increases in PaO2, with the mean PaO2 rising from 63 +/- 4 (mean +/- SEM) to 76 +/- 8 mm Hg. Peak inspiratory pressure fell from 44 +/- 4 to 39 +/- 2 cm H2O. There were no significant changes in any hemodynamic or oxygen metabolism variable associated with the institution of PC-IRV. In particular, no significant alteration in cardiac index, pulmonary artery pressures, oxygen delivery, oxygen consumption, or oxygen extraction ratio occurred with the use of PC-IRV. These results suggest that PC-IRV may be a useful ventilatory modality in the treatment of severe respiratory failure since it results in improvement in arterial oxygenation without any deterioration in hemodynamic or tissue oxygen metabolism parameters.
在9例严重呼吸衰竭患者中，于吸气与呼气比为2:1的压力控制反比通气（PC - IRV）开始前和开始后测量了心肺功能值。所有患者的动脉血氧分压（PaO₂）均升高，平均PaO₂从63±4（均值±标准误）升至76±8 mmHg。吸气峰压从44±4降至39±2 cmH₂O。与采用PC - IRV相关的任何血流动力学或氧代谢变量均无显著变化。特别是，使用PC - IRV时，心脏指数、肺动脉压、氧输送、氧消耗或氧摄取率均无显著改变。这些结果表明，PC - IRV可能是治疗严重呼吸衰竭的一种有用的通气方式，因为它能改善动脉氧合，而不会使血流动力学或组织氧代谢参数恶化。
