Li Fang, Jiang Zhi-Xin, Hao Peng, Li Xuan
Tianjin Key Laboratory of Ophthalmology and Vision Science (F.L., Z.-X.J., P.H., X.L.), Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin, China; and Medical School of Nankai University (F.L.), Tianjin, China.
Eye Contact Lens. 2016 Mar;42(2):141-6. doi: 10.1097/ICL.0000000000000132.
To assess the change of central corneal thickness (CCT) in the treatment of orthokeratology in patients with myopia.
A systematic search of all relevant studies published through April 2014 was conducted, and 95% confidence intervals (CI) of CCT change were calculated. Random or fixed-effects models were used according to heterogeneity. Publication bias of the articles was evaluated using funnel plots and Begg test.
A total of 10 studies with 239 patients (339 eyes) from clinical studies were included. Central corneal thickness reduced significantly from 1 day to 1 week by 5.73 μm (95% CI, 1.75-9.70 μm; P=0.005), and a significant mean reduction of 5.89 μm also occurred from 1 day to 1 month (95% CI, 3.50-8.29 μm; P<0.001). No significant reduction was found between 1 week and 1 month (P=0.32).
Our meta-analysis demonstrated that most reduction of CCT occurred during the first week and remained thinner for 1 month. Further randomized controlled trials with larger sample sizes, standardized outcome measurements, and different follow-up periods are warranted to find the precise change.
评估近视患者角膜塑形术治疗过程中中央角膜厚度（CCT）的变化。
对截至2014年4月发表的所有相关研究进行系统检索，并计算CCT变化的95%置信区间（CI）。根据异质性采用随机或固定效应模型。使用漏斗图和Begg检验评估文章的发表偏倚。
共纳入10项临床研究中的239例患者（339只眼）。从第1天到第1周，中央角膜厚度显著降低5.73μm（95%CI，1.75 - 9.70μm；P = 0.005），从第1天到第1个月平均也显著降低5.89μm（95%CI，3.50 - 8.29μm；P < 0.001）。在第1周和第1个月之间未发现显著降低（P = 0.32）。
我们的荟萃分析表明，CCT的大部分降低发生在第一周，并且在1个月内保持较薄。需要进一步开展样本量更大、结局测量标准化且随访期不同的随机对照试验，以明确确切变化。
