Rasola Andrea, Bernardi Paolo
Department of Biomedical Sciences and CNR Neuroscience Institute, University of Padova, Italy.
Cell Calcium. 2015 Jul;58(1):18-26. doi: 10.1016/j.ceca.2015.03.004. Epub 2015 Mar 28.
This review covers recent progress on the nature of the mitochondrial permeability transition pore (PTP) – a key effector in the mitochondrial pathways to cell death – and on the adaptive responses of tumor cells that desensitize the PTP to Ca(2+) and reactive oxygen species (ROS), thereby playing an important role in the resistance of tumors to cell death. The discovery that the PTP forms from dimers of F-ATP synthase; and the definition of the Ca(2+)- and ROS-dependent signaling pathways affecting the transition of the F-ATP synthase from an energy-conserving to an energy-dissipating device open new perspectives for therapeutic intervention in cancer cells.
本综述涵盖了线粒体通透性转换孔（PTP）本质方面的最新进展——细胞死亡线粒体途径中的关键效应器——以及肿瘤细胞的适应性反应，这些反应使PTP对Ca(2+)和活性氧（ROS）不敏感，从而在肿瘤对细胞死亡的抗性中发挥重要作用。PTP由F-ATP合酶二聚体形成这一发现；以及影响F-ATP合酶从能量保守装置转变为能量耗散装置的Ca(2+)和ROS依赖性信号通路的定义，为癌细胞的治疗干预开辟了新的前景。
