National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China; Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China; State Key Laboratory of New Pharmaceutical Preparations and Excipients, China Shijiazhuang Pharmaceutical Group Co., Ltd., Shijiazhuang 050051, China.
Pharmaceutical Biophysics Group, Institute of Pharmaceutical Science, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
J Control Release. 2015 May 28;206:206-19. doi: 10.1016/j.jconrel.2015.03.030. Epub 2015 Mar 27.
Zein is a class of alcohol-soluble prolamine proteins present in maize endosperm, which was approved as a generally recognized as safe (GRAS) excipient in 1985 by the United States Food and Drug Administration (US-FDA) for film coating of pharmaceuticals, e.g., tablets. Despite its long-term application in tablet production, effects of zein coating on tablet properties are still not fully understood. Moreover, many studies have also been conducted to illustrate its potential as an active ingredient of direct compressed tablets and film-based delivery carriers. In addition, the use of zein as a functional film coating material for new biomedical applications was also widely investigated in recent reports, which involved medical devices, nanoparticles, quantum dots and nanofibers. In this review, the present status of zein in the form of a thin film and uniform layer for use as a biomedical material is discussed. In addition, studies related to the behaviors and properties of zein films are also summarized and analyzed based on published works to gain mechanistic insights into the relationship between zein film and various improved profiles. This review will benefit future prospects of the use of zein film in drug delivery and biomedical applications.
玉米醇溶蛋白是存在于玉米胚乳中的一类醇溶性蛋白，1985 年美国食品和药物管理局（US-FDA）批准其作为制药（如片剂）薄膜包衣的一般公认安全（GRAS）赋形剂。尽管玉米醇溶蛋白在片剂生产中的应用已有很长时间，但它对片剂性质的影响仍不完全清楚。此外，许多研究也表明其作为直接压片和基于薄膜的药物传递载体的活性成分的潜力。此外，在最近的报告中，还广泛研究了玉米醇溶蛋白作为新型生物医学应用的功能性薄膜包衣材料的用途，涉及医疗器械、纳米粒子、量子点和纳米纤维。在这篇综述中，讨论了玉米醇溶蛋白作为生物医学材料的薄膜和均匀层的现状。此外，还根据已发表的研究工作对与玉米醇溶蛋白膜的行为和性质相关的研究进行了总结和分析，以深入了解玉米醇溶蛋白膜与各种改进特性之间的关系。这篇综述将有助于未来玉米醇溶蛋白膜在药物传递和生物医学应用中的应用前景。
