Zhang Yong, Cui Lili, Li Feng, Shi Nianqiu, Li Chunlei, Yu Xianghui, Chen Yan, Kong Wei
National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China; Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China; State Key Laboratory of New Pharmaceutical Preparations and Excipients, Shijiazhuang 050051, China.
Pharmaceutical Biophysics Group, Institute of Pharmaceutical Science, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
Int J Pharm. 2016 Nov 20;513(1-2):191-210. doi: 10.1016/j.ijpharm.2016.09.023. Epub 2016 Sep 9.
Nano/micro-carrier systems have shown promising application in the biomedical field as various delivery carriers. The composite material and fabrication method determine their microstructures, properties and thus their potential applications. Since approved as tablet coating material by the U.S. Food and Drug Administration (US-FDA), zein has been widely investigated as one of protein-based materials in the past few decades. Zein is renewable, biodegradable and relatively inexpensive in comparison with animal proteins (e.g., gelatin and albumin). This paper reviews the current landscape of zein-based nano/micro-carrier systems, with particular emphasis on nano/microparticles, nano/microcapsules and their design, fabrication, assembly mechanisms and biomedical applications especially for controlled drug delivery. The benefits, challenges and related solutions of zein-based colloidal carrier systems are also discussed. In addition, investigations on the molecular structure, biocompatibility and immunogenicity of zein are summarized and discussed.
纳米/微载体系统作为各种递送载体，在生物医学领域已显示出有前景的应用。复合材料和制造方法决定了它们的微观结构、性能，进而决定了它们的潜在应用。自被美国食品药品监督管理局（US-FDA）批准为片剂包衣材料以来，在过去几十年里，玉米醇溶蛋白作为一种基于蛋白质的材料受到了广泛研究。与动物蛋白（如明胶和白蛋白）相比，玉米醇溶蛋白是可再生的、可生物降解的且相对便宜。本文综述了基于玉米醇溶蛋白的纳米/微载体系统的现状，特别强调了纳米/微粒、纳米/微胶囊及其设计、制造、组装机制和生物医学应用，尤其是用于控制药物递送。还讨论了基于玉米醇溶蛋白的胶体载体系统的优点、挑战和相关解决方案。此外，对玉米醇溶蛋白的分子结构、生物相容性和免疫原性的研究进行了总结和讨论。
