增强子：等待合适的启动子。
Enhancers: holding out for the right promoter.
作者信息
Lorberbaum David S, Barolo Scott
机构信息
Department of Cell and Developmental Biology and Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Cell and Developmental Biology and Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
出版信息
Curr Biol. 2015 Mar 30;25(7):R290-3. doi: 10.1016/j.cub.2015.01.039.
Abstract
Some transcriptional enhancers work best with one type of promoter, while ignoring others. How widespread is such specificity across the genome? A new study finds that, in a fair fight, most enhancers prefer to activate promoters resembling those of their parent genes.
摘要
一些转录增强子与一种启动子配合效果最佳，而对其他启动子则不予理会。这种特异性在全基因组中普遍程度如何？一项新研究发现，在公平竞争的情况下，大多数增强子更倾向于激活与其亲本基因的启动子相似的启动子。
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本文引用的文献
1
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Nature. 2015 Feb 26;518(7540):556-9. doi: 10.1038/nature13994. Epub 2014 Dec 15.
2
Looping back to leap forward: transcription enters a new era.回溯以飞跃：转录进入新纪元。
Cell. 2014 Mar 27;157(1):13-25. doi: 10.1016/j.cell.2014.02.009.
3
Transcriptional enhancers: from properties to genome-wide predictions.转录增强子：从特性到全基因组预测。
Nat Rev Genet. 2014 Apr;15(4):272-86. doi: 10.1038/nrg3682. Epub 2014 Mar 11.
4
Perspectives on the RNA polymerase II core promoter.RNA聚合酶II核心启动子的观点。
Wiley Interdiscip Rev Dev Biol. 2012 Jan-Feb;1(1):40-51. doi: 10.1002/wdev.21. Epub 2011 Dec 6.
5
Genome-wide quantitative enhancer activity maps identified by STARR-seq.STARR-seq 鉴定的全基因组定量增强子活性图谱。
Science. 2013 Mar 1;339(6123):1074-7. doi: 10.1126/science.1232542. Epub 2013 Jan 17.
6
The NSL complex regulates housekeeping genes in Drosophila.NSL 复合物在果蝇中调节管家基因。
PLoS Genet. 2012;8(6):e1002736. doi: 10.1371/journal.pgen.1002736. Epub 2012 Jun 14.
7
The MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset.含 MOF 的 NSL 复合物与管家基因全局性地结合，但仅激活特定的子集。
Nucleic Acids Res. 2012 Feb;40(4):1509-22. doi: 10.1093/nar/gkr869. Epub 2011 Oct 27.
8
Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome.果蝇基因组中单转录起始位点和替代转录起始位点的基序组成、保守性和条件特异性。
Genome Biol. 2009;10(7):R73. doi: 10.1186/gb-2009-10-7-r73. Epub 2009 Jul 9.
9
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Nat Genet. 2007 Dec;39(12):1512-6. doi: 10.1038/ng.2007.26. Epub 2007 Nov 11.
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