Department of Surgery, Anaesthesiology, Surgical Sciences Postgraduate Program, Federal University of Rio de Janeiro (Universidade Federal do Rio de Janeiro), Rio de Janeiro, Brazil.
Bonsucesso Federal Hospital (Hospital Federal de Bonsucesso)/Brazilian Ministry of Health, Rio de Janeiro, Brazil.
Anaesthesia. 2015 Aug;70(8):956-61. doi: 10.1111/anae.12987. Epub 2015 Apr 1.
Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium-induced blockade. The aim of this study was to determine the effect of pre-treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy-three patients were randomly assigned to receive magnesium sulphate (40 mg.kg(-1) ) or saline intravenously. After anaesthetic induction, continuous train-of-four monitoring was performed and rocuronium was administered (0.6 mg.kg(-1) ). When a second twitch appeared, the patients received sugammadex (2 mg.kg(-1) ). The median (IQR [range]) reversal time of moderate neuromuscular blockade to a train-of-four ratio of 0.9 facilitated by sugammadex was 115 (93-177.5 [68-315]) s in the magnesium group and 120 (105-140 [70-298]) s in the saline group (p = 0.79). The median (IQR [range]) clinical duration was 45 (35.5-53 [22-102]) min in the magnesium group and 37 (31-43 [19-73]) min in the saline group (p = 0.031). Pre-treatment with magnesium did not significantly affect sugammadex reversal time of moderate neuromuscular blockade induced by rocuronium.
镁增强神经肌肉阻滞作用。向镁佐右旋体逆转罗库溴铵诱导的阻滞。本研究的目的是确定镁预处理对罗库溴铵诱导的神经肌肉阻滞向镁佐右旋体逆转时间的影响。73 例患者随机分为静脉注射硫酸镁（40mg/kg）或生理盐水组。麻醉诱导后，行四串刺激肌电图监测，给予罗库溴铵（0.6mg/kg）。当第二个颤搐出现时，患者接受向镁佐右旋体（2mg/kg）。硫酸镁组中，罗库溴铵诱导的中度神经肌肉阻滞时，向镁佐右旋体（TOFr 为 0.9）的中位（IQR[范围]）逆转时间为 115（93-177.5[68-315]）s，生理盐水组为 120（105-140[70-298]）s（p=0.79）。硫酸镁组的临床持续时间中位数（IQR[范围]）为 45（35.5-53[22-102]）min，生理盐水组为 37（31-43[19-73]）min（p=0.031）。罗库溴铵诱导的中度神经肌肉阻滞时，镁预处理对向镁佐右旋体的逆转时间无显著影响。
