Wang Dan, Lin Huiming, Jiang Jingjie, Jin Qumei, Li Lei, Dong Yan, Qu Fengyu
State Key Laboratory of Photoelectric Band Gap Materials, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, People's Republic of China.
IET Nanobiotechnol. 2015 Apr;9(2):58-65. doi: 10.1049/iet-nbt.2013.0011.
Hierarchical porous fibre scaffolds with mesoporous bioglasses (MBGs) and polylactic acid (PLA) were successfully fabricated by the electrospinning method. These compound scaffolds possess macropores with sizes of about 100 nm because of the solvent evaporation from the fibre and the mesoporous structure ( ∼4.0 nm) originated from MBGs. The biomineralisation ability was investigated in simulated body fluid. The fibre structure is beneficial for inducing the growth of hydroxyapatite. In addition, compared with pure MBGs, the materials (MP-1 and MP-2) exhibit a long-acting drug release process up to 140 h and the drug release process corresponds with the Fickian diffusion mechanism. With the special fibre morphology and the hierarchical porous structure, the MBGs/PLA fibre scaffolds are expected to have potential application for bone tissue repair and regeneration.
通过静电纺丝法成功制备了含有介孔生物玻璃（MBG）和聚乳酸（PLA）的分级多孔纤维支架。由于纤维中溶剂的蒸发，这些复合支架具有尺寸约为100nm的大孔以及源自MBG的介孔结构（约4.0nm）。在模拟体液中研究了其生物矿化能力。纤维结构有利于诱导羟基磷灰石的生长。此外，与纯MBG相比，材料（MP-1和MP-2）表现出长达140小时的长效药物释放过程，且药物释放过程符合菲克扩散机制。凭借特殊的纤维形态和分级多孔结构，MBG/PLA纤维支架有望在骨组织修复和再生方面具有潜在应用。
