da Silva Taís Kereski, Berbigier Marina Carvalho, Rubin Bibiana de Almeida, Moraes Rafael Barberena, Corrêa Souza Gabriela, Schweigert Perry Ingrid Dalira
Multiprofessional Integrated Residency Program in Health, with emphasis on Critical Adults, Hospital de Clínicas de Porto Alegre, Brazil Food and Nutrition Research Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil.
Food and Nutrition Research Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil Nutrition and Dietetics Service, Hospital de Clínicas de Porto Alegre, Brazil.
Nutr Clin Pract. 2015 Apr;30(2):261-5. doi: 10.1177/0884533615572150.
Phase angle (PA) is interpreted as an indicator of cell membrane integrity and a prognostic indicator in some clinical situations. This study aims to evaluate PA as a prognostic marker in critically ill patients admitted to the intensive care unit (ICU) and associate this marker with length of hospital stay, mortality, and clinical scores.
A cohort study was conducted with 95 patients aged ≥18 years admitted to the ICU, who were assessed in terms of prognostic indexes (Acute Physiology and Chronic Health Evaluation II [APACHE II] and Sequential Organ Failure Assessment [SOFA]), clinical evolution (ICU discharge, death, and length of ICU stay), and PA.
Patients were predominantly male (63.1%) and had a mean age of 63.7 ± 14.6 years; length of stay of 4 days (range, 3-9 days); mortality of 15.8%; mean APACHE II and SOFA scores of 17.3 ± 8.2 and 6.1 ± 3.1 points, respectively; and mean PA of 4.91 ± 1.36°. An association was observed between females and PA <5.1° (P = .035), which was the cutoff point determined from the receiver operating characteristic curve. PA was correlated with APACHE II score (r = -0.241; P = .02). This correlation became moderate only when patients without sepsis were considered (r = -0.506; P < .001).
PA seems to be a good prognostic marker for patients without sepsis. The weak correlation between PA and APACHE II score and the lack of association with other clinical outcomes are limitations for interpreting the prognostic value of PA in the entire study sample.
相角（PA）在某些临床情况下被视为细胞膜完整性的指标和预后指标。本研究旨在评估PA作为重症监护病房（ICU）收治的危重症患者的预后标志物，并将该标志物与住院时间、死亡率和临床评分相关联。
对95名年龄≥18岁入住ICU的患者进行了队列研究，对其预后指标（急性生理与慢性健康状况评分系统II [APACHE II]和序贯器官衰竭评估 [SOFA]）、临床病程（ICU出院、死亡和ICU住院时间）以及PA进行了评估。
患者以男性为主（63.1%），平均年龄为63.7±14.6岁；住院时间为4天（范围3 - 9天）；死亡率为15.8%；APACHE II和SOFA评分的平均值分别为17.3±8.2分和6.1±3.1分；PA的平均值为4.91±1.36°。观察到女性与PA<5.1°之间存在关联（P = 0.035），这是根据受试者工作特征曲线确定的临界值。PA与APACHE II评分相关（r = -0.241；P = 0.02）。仅在考虑无脓毒症的患者时，这种相关性才变得中等（r = -0.506；P < 0.001）。
PA似乎是无脓毒症患者的良好预后标志物。PA与APACHE II评分之间的弱相关性以及与其他临床结局缺乏关联是在整个研究样本中解释PA预后价值的局限性。
